The Correction of Deep Facial Wrinkles using Preserved Particulate Fascia Lata

Jung, Youngwon; Hong, Joonpio

Abstract

Preserved particulate fascia lata, derived from screened human cadavers, has recently become available. This injectable form of the material can be injected when soft tissue augmentation is desired. Historically, preserved fascia grafts have proven efficacy and an excellent safety record over the past 70 years. Deep facial wrinkles, especially grabellar frown and nasolabial fold remain a difficult problem to be corrected. Clinical subjects(N=35; 29 women, 6 men, age range 29 - 48 years) requiring soft tissue augmentation to correct deep facial wrinkles were injected with a total of 53 syringes of freeze-dried, irradiated, human cadaver fascia lata. After an subdermal pocket was created at each depressed site, two different preparations -2.0 mm, 0.5 mm particle sizes-were hydrated in 2 - 3 cc normal saline and injected with needles ranging in size from 16 to 20 gauge. The patients were followed for 9 months (1-17 months) after implantation without incidence of infection, allergic reaction, or acute rejection. After the treatment day, patients experienced no further discomfort. No dermal inflammation was evident and the local ecchymosis associated with infections was minor. Soft tissue augmentation was evident 6 months after grafting or longer in most cases. Ultimately, a predictable improvement in skin contour occurred in the majority of the facial wrinkles.Preserved particulate fascia lata grafting is a simple, safe, controlled technique for correction of facial wrinkles. This patient series indicates that injectable preparations of preserved fascia lata have the high biocompatibility as experienced with whole-tissue implants.