J Korean Surg Soc.  2005 Sep;69(3):204-209.

Expression of p53 and Vascular Endothelial Growth Factor in Gastric Cancer; Usefullness as Clinical Significance

• Kim SH
• Park PJ
• Ryu WS
• Kim J
• Cho MY
• Bae JW
• Kim CS
• Kim YC
• Whang CW
• Suh SO

Abstract

PURPOSE
Recent studies have indicated that the p53 tumor suppressor gene and vascular endothelial growth factor (VEGF) play an important role in the angiogenic process of tumors. In this study, the correlation of the expressions of p53 and VEGF and the clinical features in gastric cancer were investigated. METHODS: The expressions of p53 and VEGF in gastric cancer were determined using immunohistochemistry on 98 randomly selected gastric cancer patients that had received curative resection. RESULTS: The expression of p53 and VEGF were observed in 51% and 50% of tumors, respectively. A significant correlation was found between p53 expression and the tumor histological type (P=0.045). The higher the TNM stage, the higher the observed level of p53 expression. The p53 and VEGF expression stati coincided in 70.4% of tumors, with a significant correlation found between the p53 and VEGF stati. Significantly worse survival rates were found in p53-positive and VEGF-positive patients than in those that were p53-negative and VEGF-negative. CONCLUSION: The present results indicated that p53 and VEGF expressions are useful in predicting the prognosis of patients with gastric cancer.

Keyword

Gastic cancer; p53; Vascular endothelial growth factor (VEGF)

MeSH Terms

Genes, Tumor Suppressor
Humans
Immunohistochemistry
Prognosis
Stomach Neoplasms*
Survival Rate
Vascular Endothelial Growth Factor A*
Vascular Endothelial Growth Factor A