Korean Circ J.  1990 Sep;20(3):474-478. 10.4070/kcj.1990.20.3.474.

Clinical Effects of Arotinolol in Essential Hypertension

• Park YK
• Kim AM
• Jeong JW
• Park OK

• KMID: 1938113
• DOI: http://doi.org/10.4070/kcj.1990.20.3.474

Abstract

To evaluate the antihypertensive effect, side effects and metabolic changes of arotinolol, a combined alpha and beta blocker, 10-15mg of arotinolol twice a day was administered for 8 weeks in 27 hypertensives (168+/-16/106+/-10mmHg) without heart failure, bradycardia, conduction disturbance, coronary heart disease or renal impairment. Blood pressure decreased to 137+/-10/90+/-6mmHg and average reduction of systolic BP and diastolic BP were 31 mmHg(18%) and 16mmHg(15%) respectively. Pulse rate reduced significantly(p<0.01) after 2weeks' treatment of arotinolol and average reduction of pulse rate was 10 beats/min after 8weeks treatment. There were no significant changes of serum ALP, AST and ALT, BUN, and serum creatinine, Na+, K+, total cholesterol, HDL cholesterol and triglyceride. But in 8 patients(30%), insomina, sleepness, cold extrimities or numbness on extremities developed or aggravated. These results suggest that arotinolol be an useful antihypertensive agent in hypertensives without heart failure, bradyarrhythmais or peripheral vascular disease.

Keyword

Hypertension; Arotinolol

MeSH Terms

Blood Pressure
Bradycardia
Cholesterol
Cholesterol, HDL
Coronary Disease
Creatinine
Extremities
Heart Failure
Heart Rate
Hypertension*
Hypesthesia
Peripheral Vascular Diseases
Triglycerides
Cholesterol
Cholesterol, HDL
Creatinine