Korean J Anesthesiol.  2003 Nov;45(5):632-635. 10.4097/kjae.2003.45.5.632.

Changes in Middle Cerebral Artery Blood Flow Velocity after the Intravenous Injection of Lidocaine by Transcranial Doppler

• Kim YJ
• Park SW
• Lee KM
• Cheong SH
• Choe YK
• Park JW
• Shin CM
• Park JY

• KMID: 1935954
• DOI: http://doi.org/10.4097/kjae.2003.45.5.632

Abstract

BACKGROUND: Lidocaine is used for suppressing circulatory responses to endotracheal intubation. In this study the investigated changes of middle cerebral artery blood flow velocity (Vmca) before and after intravenous lidocaine injection by transcranial doppler.
METHODS
Fifteen healthy volunteers received a bolus dose of intravenous lidocaine 1.5 mg/kg. Vmca's were measured on the temple using a bidirectional 2-MHz transcranial doppler probe before and after lidocaine injection. Vmca's were recorded continually every 10 sec for 10 minutes after lidocaine injection.
RESULTS
Mean Vmca was 67.6 +/- 7.6 cm/sec before lidocaine injection. Maximal Vmca's (70.7 +/- 7.5 cm/sec, P<0.05) occurred 35 +/- 16 sec after lidocaine injection, and then the Vmca decreased gradually. Minimal Vmca's (56.6 +/- 7.4 cm/sec, P<0.05) were measured at 164 +/- 40 sec after lidocaine injection.
CONCLUSIONS
We suggest that lidocaine generally causes the decreases in Vmca, excepting the temporarily increase in Vmca about 35 sec after a single bolus administration of intravenous lidocaine.

Keyword

cerebral arterial blood flow velocity; lidocaine; transcranial doppler

MeSH Terms

Blood Flow Velocity*
Healthy Volunteers
Injections, Intravenous*
Intubation, Intratracheal
Lidocaine*
Middle Cerebral Artery*
Lidocaine