Effect of Olanzapine on Alcohol Consumption of C57BL-6 Type Rats

Han, Sang Woo; Jun, Yong Ho; Jung, Hee Yeon

Abstract

OBJECTIVE
This study compared the effect of anticraving agent acamprosate and atypical antipsychotics that has serotonin-dopamine receptor antagonistic property, olanzapine on reduction of alcohol consumption level of alcohol intake reinforced C57BL-6 type rat.
METHODS
Small amount of alcohol and water were applied to the 28 rats for 2 hours per day during 30 days. On the 31th day, the rats were divided into four groups and provided different medication by intraabdominal route 30 minutes before the alcohol consumption. For the next 7 weeks, the each subject group was applied with acamprosate 200 mg/kg, olanzapine 0.1 mg/kg and olanzapine 1.0 mg/kg respectively and the control group was done with saline.
RESULTS
In contrast to control group, acamprosate 200 mg/kg group and olanzapine 0.1 mg/kg showed the reduction of alcohol consumption from 3rd to 7th week period, significantly. Although olanzapine 1 mg/kg group showed a momentary decrease of the consumption during the from 3rd to 6th weeks, the group did not show significant difference at 7th week. Olanzapine 0.1 mg/kg was more effective in reducing the alcohol consumption than olanzapine 1 mg/kg.
CONCLUSION
This results suggest that low dose of olanzapine may reduce the alcohol intake in C57BL-6 type rats, as well as acamprosate.