Korean J Anesthesiol.  1999 Jan;36(1):21-26. 10.4097/kjae.1999.36.1.21.

Neuromuscular Blocking Effect of Vecuronium in Electric Burned Patients for Endotracheal Intubation

• Bae SJ
• Kwon EJ
• Noh GJ
• Jeong HJ
• Lee HJ
• Kim KS

• KMID: 1935119
• DOI: http://doi.org/10.4097/kjae.1999.36.1.21

Abstract

BACKGROUND: In inducing anesthesia for burn patients, nondepolarizing muscle relaxant (NDMR) is usually used, because succinylcholine, a widely used muscle relaxant may cause hyperkalemia. It is well known that because burn patients show resistance to NDMR, a high dose of NDMR is needed for them. In this study, we wanted to know whether there is significant difference of the relaxation effect between 0.1 mg/Kg and 0.15 mg/Kg dose's of vecuronium, and between burn and unburn patients.
METHODS
Subjects are 40 male patients having 1 or 2 ASA physical status (20 are burn patients and the other 20 are unburn patients). We divided them into 4 groups; 1) Group BI (burn patients, vecuronium 0.1 mg/Kg) 2) Group BII (burn Pts, vecuronium 0.15 mg/Kg) 3) Group UBI (unburn Pts, vecuronium 0.1 mg/Kg) 4) Group UBII (unburn Pts, vecuronium 0.15 mg/Kg). Average onset times (time from injection of vecuronium to zero first twitch height (T1)) were measured and intubating condition were scored on 0 to 4 scale.
RESULTS
The onset time of vecuronium and distribution of intubation scores didn't show statistical differences among 4 groups.
CONCLUSION
The onset time of vecuronium and intubating condition in burn patients dosen't show a difference from unburn patient.

Keyword

Monitoring, train-of-four; Neuromuscular relaxants, vecuronium; Skin, burn

MeSH Terms

Anesthesia
Burns
Burns, Electric*
Humans
Hyperkalemia
Intubation
Intubation, Intratracheal*
Male
Neuromuscular Blockade*
Neuromuscular Monitoring
Relaxation
Succinylcholine
Vecuronium Bromide*
Succinylcholine
Vecuronium Bromide