Korean J Blood Transfus.  1999 Dec;10(2):221-227.

A Case of Delayed Hemolytic Transfusion Reaction with Acute Renal Failure Caused by Anti-E Antibody

• Kang MS
• Byun JW
• Yoon CO
• Kim IS

Abstract

A delayed hemolytic transfusion reaction (DHTR) is the result of delayed anamnestic alloantibody response four to fourteen days after transfusion of apparently compatible blood. Most DHTRs are very mild and may not be recognized clinically. Some are manifested only by anemia. Only a few cases are severe enough to induce a massive hemolytic reaction followed by frank renal failure. Recently, we experienced a case of DHTR with acute renal failure (ARF) due to anti-E. A 21-year-old woman received compatible four units of packed red cells after right artificial total hip replacement arthroplasty due to juvenile rheumatoid arthritis. She had a history of transfusion 4 years ago. Fourteen days after the transfusion, she showed a fall in hematocrit, hemoglobinuria and a positive indirect antiglobulin test, and accompanied by ARF. Anti-E was identified in the patient's serum by antibody screening and identification test at that time. She recovered from ARF after hemodialysis with conservative management. However, eventually, she died due to disseminated intravascular coagulopathy.

Keyword

Delayed hemolytic transfusion reaction; Acute renal failure; Anti-E

MeSH Terms

Acute Kidney Injury*
Anemia
Arthritis, Juvenile
Arthroplasty
Arthroplasty, Replacement, Hip
Blood Group Incompatibility*
Coombs Test
Female
Hematocrit
Hemoglobinuria
Humans
Mass Screening
Renal Dialysis
Renal Insufficiency
Young Adult