Assessment of Irritancy to Sodium Lauryl Sulfate in Man by Laser Doppler Velocimetry

Rhee, Jeong Ki; Kim, Hyung Ok; Kim, Jeung Kyu; Kim, Chung Won

Abstract

It is desirable to use more safe, objective, non-invasive method than visual scoring for the evaluation of irritation reaction and determine the optimum eoncentration of sodium lauryl sulfate(SLS) as a positive irritant control in routine patch test. In this study, SLS was applied to the volar forearm of ll non-atopic, healthy volunteers in concentrations of 0.5, 1.0, 2.0, and 5.0% under occlusion for 24h. The blood flow in test sites exposed to SLS was tecorded by laser Doppler velocimetry (LDV). The test sites were scored visually and the skin blood flow was measured at 24h, 48h, and 72h after the application of FiLS. We obtained the following results,' 1. There was a good correlation between visual scoring and skin blood flow using LDV(p = 0.4547). 2. 5.0% SLS could be used as a positive irritant control in routine patch test (p<0,05).