Korean J Obstet Gynecol.
2002 Aug;45(8):1360-1366.
The Effects of Low Dose Estrogen Replacement Therapy on the Lipid Profile of Postmenopausal Women
- Affiliations
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- 1Department of Obstetrics and Gynecology, School of Medicine, Kosin university, Busan, Korea.
- 2Department of Internal Medicine, School of Medicine, Kosin university, Busan, Korea.
Abstract
OBJECTIVE
To evaluate the effects of low dose estrogen replacement therapy on the lipid profile in the postmenopausal women.
METHODS
This prospective randomized clinical trial examined the effects of low dose conjugated equine estrogen on lipid profile in 140 postmenopausal women. Treatment included 0.625 mg conjugated equine estrogen (group I, n=75), or 0.31mg conjugated equine estrogen (group II, n=55) for 12 months. Lipid profile were performed at months 6 and 12 months.
RESULTS
HDL cholesterol increased significantly during the treatment in Group I and Group II. LDL cholesterol decreased significantly during the treatment in Group I and Group II. Total cholesterol in Group I and Group II decreased during treatment, but not significantly. As triglyceride increased slightly during the treatment in Group I and Group II but not significantly.
CONCLUSION
The low dose conjugated equine estrogen is also positive changes on lipid profile.
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