The Clinical Change of Bone Mineral Density after Surgery and Hormone Replacement Therapy on Menopausal Woman

Ryu, Kyung Chul; Kim, Young Ho; Jung, Hyuk

Abstract

The objective of this study is to compare bone mineral densities(BMD) between the symptomatic menopausal women and the asymptomatic menopausal women, between the spontaneous menopausal group and the surgical menopausal group, and especially between the HRT group and no-HRT group. From January, 1995 to December 1995, this study was prospectively analysed in 96 menopausal women(47 spontaneous menopausal women, 23 surgical nopausal women) who were admitted to Department of Obstetrics and Gynecology, Chosun University Hospital for HRT. The all women was measured T-score of bone mineral densities at L1, L2, L3 and L4 of lumbar spine and neck, trochanter, ward`s area of femur from dual-energy X-ray absorptiometry(DEXA). Student t-test and chi-squre test were used for statistical comparison. The results obtained were as follows: 1. The mean age of the osteoporotic group(54.96 +/- 6.6) is higher than the non-osteoporotic group(50.55 +/- 81). 2. No difference is detected in the BMD between the surgical menopausal group and the spontaneous menopausal group, because duration of the follow-up is too short and the study group is too small perhaps. 3. Descent of T-score in the symtomatic menopausal women is not severe than the asymptomatic group, but especially in L4 area, T-score of the symptomatic group(-1.76 +/- 1.3 < -1.04 +/- 1.4) is more decreased(p<0.04). 4. T-score between the long term HRT group and the no-HRT group is different markedly. HRT during only 1 year is not attributed to BMD loss. So the continuous HRT over 1 year and Follow-up is need to improvement of BMD in the menopausal women with risk factors.