Korean J Hepatobiliary Pancreat Surg.  2010 Mar;14(1):1-9.

The Discriminating Ability of a Prognosis According to the TNM, Okuda, CLIP, JIS, and BCLC Staging Systems for Hepatocellular Carcinoma

• Koo HY
• Kwon SW
• Lee HY
• Hwang SK
• Lim KS
• Kim MD

Abstract

PURPOSE
There is yet no ideal single staging system for hepatocellular carcinoma (HCC). The aim of this study was to analyze HCC survival times according to the TNM, Okuda, CLIP, JIS, and BCLC staging systems and their prognostic discrimination ability.
METHODS
A retrospective analysis of medical records and statistical data from the Korean statistical information service was done for HCC patients diagnosed at Bundang CHA hospital between June, 1992 and February, 2009.
RESULTS
During follow-up, 121 (72%) of 168 people died and 1, 3 and 5 year overall survival rates were, respectively, 58%, 35% and 25%. In the analysis of discriminative ability of each staging system, the CLIP staging system showed the highest LR chi-square value, and the lowest AIC value (p<0.05). Therefore, the CLIP staging system appears to be superior to the other systems.
CONCLUSION
Of the 5 staging systems in this study, the CLIP staging system was superior to the other systems, but the results of many other studies from different countries have varied. It is necessary to establish the staging system suitable for each country's actual circumstances.

Keyword

Hepatocellular carcinoma; Staging system; Survival analysis; Prognosis

MeSH Terms

Carcinoma, Hepatocellular
Discrimination (Psychology)
Follow-Up Studies
Humans
Information Services
Medical Records
Prognosis
Retrospective Studies
Survival Analysis
Survival Rate