Korean J Pediatr Hematol Oncol.  2002 Oct;9(2):260-268.

Three Cases of Second Malignancy after Chemo-radiotherapy: Experiences in a Single Center

Affiliations
  • 1Department of Pediatrics, Kyungpook National University School of Medicine, Korea.
  • 2Department of Pathology, Kyungpook National University School of Medicine, Korea.
  • 3Department of Neurosurgery, Kyungpook National University School of Medicine, Korea.
  • 4Department of Therapeutic Radiology, Kyungpook National University School of Medicine, Korea.
  • 5Department of Pediatrics, Daegu Catholic University School of Medicine, Daegu, Korea.

Abstract

Although the survival rate in childhood cancer is increased with current improvements of diagnostic and therapeutic methods, the incidence of second malignancy is now increasing. Therefore close follow-up with high index of suspicion for second malignancies are important for cancer survivng patients. We report our experiences of 3 second malignancies which were glioblastoma multiforme after treatment of acute lymphoblastic lymphoma, Philadelphia positive leukemia after treatment of osteosarcoma and acute myelogenous leukemia occuring in the course of chemotherapy for acute lymphoblastic leukemia. It is imperative that survivors of childhood cancer be closely followed for the detection of not only the relapse of original disease but also the occurrence of second malignancy.

Keyword

Second malignancy; Chemotherapy; Radiotherapy

MeSH Terms

Drug Therapy
Follow-Up Studies
Glioblastoma
Humans
Incidence
Leukemia
Leukemia, Myeloid, Acute
Neoplasms, Second Primary*
Osteosarcoma
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Radiotherapy
Recurrence
Survival Rate
Survivors
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