Experimental Prostatitis Following Repeated Injection of Homologous and Heterologous Prostatic Tissue

Kim, Tei Chin; Lee, Hak Song; Lee, Chae Koo

Abstract

The mechanism of so-called auto-immune disease has been studied extensively andthe growth of a unitary theory to explain the causation of many human diseasesnow bids fair to compass virtually all ailments. This view is based on closerelation between experimental auto-allergic destruction of a particular organ andthe spontaneous human diseases affecting the organ. Evidence in the form ofcirculating antibodies reacting specifically in vitro with extracts ofappropriate organs has accumulated on a broad scale. Experimental allergicdiseases induced by repeated injection of homologous or heterologous organ andtissue antigen in company with adjuvant, based on immunological process, havebeen reported. More recently, a possible role of immunological process inmechanism of prostatitis in association with Reiter's disease has been broughtforth. This study was undertaken to know any allergic destruction of the prostateon immunologic basis as in other particular organs and tissues. In this study atotal of 45 healthy adult white rats of 7 groups were used and injection of thefollowing were given intramuscularly once a week for 6 weeks.Group 1. six rats, control, normal saline alone.Group 2. six rats, adjuvant alone.Group 3. six rats, rats prostate alone.Group 4. nine rats, rat prostate tissue with adjuvant.Group 5. six rats, rat prostate tissue with adjuvant and prednisolone.Group 6. six rats, rabbit prostate tissue alone.Group 7. six rate, rabbit prostate tissue with adjuvant.The prostate of all experimental animals were studied hislopathologically and the following results were obtained: 1. In 8 of 9 rats of the group 4 receiving homologous prostatic tissue with adjuvant, the prostate showed marked and significant inflammatory changes including diffuse or local interstitial infiltration of lymphocytes, histiocytes and eosinophiles. These changes are more marked in the ventral lobe than in the dorsal lobe. 2. These changes are so-called organ and species specific reaction based on immunological process which is initiated by stimulation of tissue antigen. 3. These allergic reaction is readily inhibited or prevented by administration of prednisolone.