Nucl Med Mol Imaging.
2007 Dec;41(6):566-569.
Quality Control of Residual Solvents in [18F]FDG Preparations by Gas Chromatography
- Affiliations
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- 1Department of Nuclear Medicine, College of Medicine and Institute of Radiation Medicine, Medical Research Center, Seoul National University, Korea. jmjng@snu.ac.kr
- 2Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
- 3Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Abstract
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PURPOSE: Analysis of volatile organic solvents in 2-deoxy-2-[18F] fluoro-D-glucose ([18F]FDG) preparations was performed by gas chromatography (GC), in accordance with USP.
MATERIALS AND METHODS
Analyses were carried out on a Hewlett-Packard 6890 gas chromatography equipped with an FID.
RESULTS
We determined the amounts of ethanol and acetonitrile on every batch of our routine [18F]FDG preparations, ranging between 5000 ppm and 100 ppm. In our routine preparation of [18F]FDG, the amount of acetonitrile and ethanol in the final product were well below the maximum allowable limit described in the USP.
CONCLUSION
Our [18F]FDG preparations were in accordance with the suggested USP maximum allowable levels of the quality control analysis of volatile organic compounds.
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