J Korean Soc Biol Psychiatry.  2000 Nov;7(2):123-130.

cDNA Microarray in Psychiatry

• Yang BH
• Kim JY

Abstract

The development of inexpensive high throughput methods to identify individual DNA sequences is important to the future growth of medical genetics. This has become increasingly apparent as psychiatric geneticists focus more attention on the molecular basis of complex multifactorial diseases at which most of psychiatric disease is estimated. Furthermore, candidate gene approaches used in identifying disease associated genes necessitate screening large sequence blocks for changes tracking with the disease state. Even after such genes are isolated, large scale mutational analysis will often be needed for risk assessment studies to define the likely medical consequences of carrying a mutated gene. This review provide basic knowledge of up-to-date technology, cDNA microarray which enables above mentioned various research themes.

MeSH Terms

Base Sequence
DNA, Complementary*
Genetics, Medical
Mass Screening
Oligonucleotide Array Sequence Analysis*
Risk Assessment
DNA, Complementary