J Korean Soc Radiol.  2014 Jan;70(1):65-69. 10.3348/jksr.2014.70.1.65.

Giant Cell Reparative Granuloma in Soft Tissue of Foot: A Case Report

• Park GM
• Lee J
• Kang MJ
• Lee HB
• Bae KE
• Kim JH
• Kim HJ

• KMID: 1897263
• DOI: http://doi.org/10.3348/jksr.2014.70.1.65

Abstract

Giant cell reparative granuloma is a benign reactive process following intraosseous hemorrhage rather than a true tumor. This lesion most commonly affects the maxilla and mandible, followed by phalanges, hands, and feet. Local invasion of surrounding soft tissue is a typical feature of giant cell reparative granuloma in the bones of the upper and lower limbs. We present the rare case of giant cell reparative granuloma arising from soft tissue of the foot without erosion or engulfing of the adjacent bone.

MeSH Terms

Foot*
Giant Cells*
Granuloma*
Hand
Hemorrhage
Lower Extremity
Mandible
Maxilla

Figure

• 

  Fig. 1 Giant cell reparative granuloma of soft tissue of foot in 18-year-old woman. A. Plain radiograph shows clustered and punctate soft tissue calcifications around base of first metatarsal bone (arrow). B, C. Coronal MR images reveal a moderately defined intermuscular mass (arrows) between flexor hallucis brevis (FH), lumbricallis (Lu), and adductor hallucis (AH) muscle, showing heterogeneous high signal intensity on fat-suppressed T2-weighted image (B) and mixed intermediate and low signal intensity on T1-weighted image (C). D, E. Coronal (D) and sagittal (E) gadolineum enhanced fat-suppressed T1-weighted images reveal heterogeneous enhancement of the lesion (arrows). F-H. Photomicrograph of surgical specimen shows embedded bony mass in skeletal muscle and fatty tissue (H&E stain, × 10) (F), consists of fibrous stromal tissue in reactive bone formation (abundant osteochondral matrix) (H&E stain, × 100) (G) and spindle cell (fibroblasts) without atypia, arranged in a whorled to fascicular pattern and occasionally admixed osteoclastic giant cells (H&E stain, × 400) (H).

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