Korean J Perinatol.  2015 Jun;26(2):121-127. 10.14734/kjp.2015.26.2.121.

Clinical Characteristics of Meconium Aspiration Syndrome according to Ventilator Care

• Lim RK
• Bae MH
• Kim AY
• Han YM
• Park KH
• Byun SY

• KMID: 1896936
• DOI: http://doi.org/10.14734/kjp.2015.26.2.121

Abstract

PURPOSE
Meconium aspiration syndrome is an important cause of neonatal morbidity and mortality, and sometimes patients need mechanical ventilator therapy. The aim of this study was to identify the risk factors which required mechanical ventilation.
METHODS
We retrospectively analyzed 44 infants diagnosed as meconium aspiration syndrome from January 2009 to December 2013. We divided into 2 groups (ventilator group and oxygen therapy group) and analyzed the clinical characteristics, vital signs, laboratory findings and clinical courses.
RESULTS
Ventilator group and oxygen therapy group included each 22 infants, and there were no significant differences in clinical characteristics between two groups. Time to transfer and time to start oxygen therapy were longer in ventilator group but not statistical difference. Initial mean blood pressure and pH were significantly lower in ventilator group than in oxygen therapy group (P=0.026, P=0.003). Ventilator group had longer treatment period and worse prognosis than oxygen therapy group.
CONCLUSION
If the infants with meconium aspiration and respiratory distress represent low pH and hypotension, we have to pay close attention to early oxygen supplementation and proper treatment to prevent poor clinical course.

Keyword

Meconium aspiration syndrome; Ventilator care; Risk factors

MeSH Terms

Blood Pressure
Humans
Hydrogen-Ion Concentration
Hypotension
Infant
Infant, Newborn
Meconium Aspiration Syndrome*
Mortality
Oxygen
Prognosis
Respiration, Artificial
Retrospective Studies
Risk Factors
Ventilators, Mechanical*
Vital Signs
Oxygen

Reference

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