J Korean Surg Soc.  2003 Apr;64(4):358-363.

Carcinoid Tumor of the Ampulla of Vater

• Kim JI
• Kim KH
• Kim JI
• Park YJ
• Kim HS
• Park SH
• Lee MS
• Kim CN
• Chang SH
• Song BJ

Abstract

Carcinoid tumors of the ampulla of Vater are extremely rare, and due to their location jaundice in approximately 2/3 of patients. A previously healthy 58-year-old man suffered from indigestion for one year. An abdominal CT and endoscopic ultrasonography showed a relatively well-enhancing mass (2.5 cm in size) at the ampulla of Vater and dilatation of the bile ducts. A duodenoscopy showed a luminally protruding mass, with preserved mucosa, at the ampulla of Vater. So a radical pancreatoduodenectomy was performed. From the operation a 2.3x2.3x2.0 cm-sized submucosal tumor at the ampulla of Vater was found. The cut surface of the tumor had a well circumscribed yellowish fine granular appearance, with a pushing tumor border. Histopathologically the tumor revealed tubular, trabecular and ribbon-like arrangements of tumor cells. The tumor cells had hyperchromatic round nuclei, with coarsely clumped chromatin and indistinct nucleoli. The neoplastic cells were diffusely and strongly immunoreactive for synaptophysin, chromogranin and CD56. We report the experience of a carcinoid tumor at the ampulla of Vater.

Keyword

Carcinoid tumor; Ampulla of Vater

MeSH Terms

Ampulla of Vater*
Bile Ducts
Carcinoid Tumor*
Chromatin
Dilatation
Duodenoscopy
Dyspepsia
Endosonography
Humans
Jaundice
Middle Aged
Mucous Membrane
Pancreaticoduodenectomy
Synaptophysin
Tomography, X-Ray Computed
Chromatin
Synaptophysin