Korean J Fertil Steril.
2001 Jun;28(2):105-110.
A Study of Protein S Deficiency in Antiphospholipid Syndrome
- Affiliations
-
- 1Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
- 2Department of Genetics, College of Medicine, Pocheon CHA University, Pocheon, Korea.
- 3Department of Clinical Pathology, College of Medicine, Pocheon CHA University, Pocheon, Korea.
- 4Department of Internal Medicine, College of Medicine, Pocheon CHA University, Pocheon, Korea.
Abstract
OBJECTIVE
To evaluate the abnormality of protein S in patients with recurrent spontaneous abortion due to antiphospholipid syndrome. MATERIALS AND METHOD: Antigen and activity of protein S were analyzed by enzyme immunoassay and clotting method, respectively.
RESULTS
Of 18 patients with antiphospholipid syndrome, 4 patients were found to have no abnormality of protein S. There were 14 cases of protein S abnormality. Among them, there were 8 cases of type 1, 1 case of type 2, and 5 cases of type 3 protein S deficiency.
CONCLUSION
So in the workup of patients with recurrent spontaneous abortion due to antiphospholipid syndrome, the evaluation for protein S is required.
