An Experimental Study on Bladder Regeneration

Yun, Jung Chul

Abstract

Mechanism and process of bladder regeneration were experimentally observed in this study, using 3S Korean mongrel dogs weighing 15~25kg. The animals were divided into two experimental groups. In the first group (A) of 27 dogs subtotal cystectomy and urinary diversion were underwent to study the influence of urine on the bladder regeneration and the second group (B) of 8 dogs in which only subtotal cystectomy was performed was investigated for the process of regeneration. In the group A the dogs were sacrificed every week in the first one month, every 2 weeks in the following 5 months and every 4 weeks thereafter. The bladder was examined morphologically and histologically and no remarkable regenerative process was observed. In the group B 8 dogs were sacrificed at intervals of 2 or 4 weeks after 6 months of initial operation. The distinct regenerated bladder was noticed and its completion took place in 36 weeks. The area of regeneration showed a definite thick walled pouch with normal uroepithelium and normal color. From these observations it is postulated that urine might have played a role in regeneration of the bladder. possibly by mechanical stimulation and a further study will be necessary to investigate a possible chemical factor.