Korean J Occup Environ Med.  2002 Jun;14(2):199-203.

Three Cases of Skin Pigmentation Caused by 2,5-Hexanedione

• Kim SA
• Jung SJ
• Lee CY
• Lee SM
• Kim SW

Abstract

OBJECTIVES
To report on the skin discoloration experienced by three workers handling 2 , 5 -hexanedione
METHODS
Three workers, who showed orange-brown discoloration of the palms during observation under the Kumi occupational disease surveillance system, had their history evaluated and underwent physical examination. A workplace survey was performed by an occupational physician and an industrial hygienist.
RESULTS
The three workers were determined to have been experiencing skin discoloration since the introduction of a new cleaning solvent. The new solvent contained 2,5-hexanedione, which is reported in the literature to be possibly capable of causing orangebrown discoloration of the skin. After discontinuation of solvent use, the workers recovered within a week.
CONCLUSIONS
These cases demonstrate that 2,5-hexanedione can produce skin pigmentation.

Keyword

Skin pigmentation; 2,5-Hexanedione; Surveillance

MeSH Terms

Gyeongsangbuk-do
Occupational Diseases
Physical Examination
Skin Pigmentation*
Skin*