Korean J Gastroenterol.  2002 Dec;40(6):355-363.

Expression of Integrin alpha5, alpha6, alphaV, beta1, beta3, beta4 Subunits in Gastric Cancer

Affiliations
  • 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. swoopark@yumc.yonsei.ac.kr
  • 2Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.
  • 3Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea.
  • 4Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.

Abstract

BACKGROUND/AIMS: The integrins play a central role in maintaining the morphology of cell and tissue, growth, differentiation, migration, survival and apoptosis of cells, and angiogenesis. Although integrins are implicated in carcinogenesis and tumor angiogenesis, their precise contributions to the process are largely unknown.
METHODS
For paraffin embedded tissue samples of 102 gastric cancers (23 differentiated, 79 undifferentiated), the expression of integrin alpha5, alpha6, alphaV, beta1, beta3, beta4 subunits and factor VIII were examined by immunohistochemical staining. The relationships between the expression of each integrin and several clinicopathologic parameters were analyzed.
RESULTS
The positive rates of integrins were as follows: alpha5 24%, beta1 8%, alpha6 16%, beta4 24%, alphaV 29%, and beta3 34%. The expression of alpha5, alpha6, and alphaV was well correlated with the expression of beta1, beta4, and beta3, respectively. The alphaV integrin was highly expressed in tumors of advanced T stage. The expressions of alpha6 and beta4 integrins were significantly higher in differentiated tumors, but the beta3 integrin was significantly expressed in undifferentiated tumors. The number of tumor vessels has positive correlation with alphaV integrin expression.
CONCLUSIONS
These findings suggest that integrin alpha6beta4 is one of the key factors in determining tumor differentiation and growth pattern. The integrin alphaV beta3 may be related to the angiogenesis especially in advanced gastric cancer.

Keyword

Stomach neoplasms; Integrin; Immunohistochemical stain

MeSH Terms

Apoptosis
Carcinogenesis
Factor VIII
Integrin alpha5*
Integrin alpha6beta4
Integrin alphaV
Integrin beta3
Integrin beta4
Integrins
Paraffin
Stomach Neoplasms*
Factor VIII
Integrin alpha5
Integrin alpha6beta4
Integrin alphaV
Integrin beta3
Integrin beta4
Integrins
Paraffin
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