Korean J Fertil Steril.  2002 Jun;29(2):97-103.

Effect of Pentoxifylline on the ICSI Program Undergone in Severe Asthenozoospermia

• Sohn JO
• Shin JS
• Jeong CJ
• Cho YS
• Oum KB
• Choi DH
• Kim HJ

Abstract

OBJECTIVE
The aim of this study was to evaluate the effect of Pentoxifylline(PF) on the conventional ICSI program undergone in severe asthenozoospermia. METHOD: Total 348 cycles of ICSI programs undertaken at CHA General Hospital from January, 1996 to September, 2000, were divided into two groups - injected with pentoxifylline-treated sperm(PFT, 204 cycles) or non-treated sperm(NPFT, 144 cycles) and the clinical results of PFT group were compared with those of NPFT.
RESULTS
PF-treatment on sperm increased their motility of normozoospermia and severe asthenozoospermia. Fertilization rate of PFT group was higher than those of ICSI programs undertaken using sperm of NPFT(70.6% vs. 62.9%, p<0.01). And, ET and clinical pregnancy rates of PFT were slightly higher than those of NPFT(93.1%, 44.2% vs. 90.3%, 36.2%).
CONCLUSION
These results showed that treatment of pentoxifylline has a beneficial role on selection of viable sperm in severe asthenozoospermia.

MeSH Terms

Asthenozoospermia*
Fertilization
Hospitals, General
Pentoxifylline*
Pregnancy Rate
Sperm Injections, Intracytoplasmic*
Spermatozoa
Pentoxifylline