Korean Circ J.
2002 Dec;32(12):1078-1084. 10.4070/kcj.2002.32.12.1078.
Heart Rate Variability Related to Symptoms in Patients with Mital Valve Prolapse Syndrome
- Affiliations
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- 1Division of Cardiology, Department of Internal Medicine Pusan National University Hospital, Busan, Korea. pnuhshin@hanmail.net
- KMID: 1858730
- DOI: http://doi.org/10.4070/kcj.2002.32.12.1078
Abstract
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BACKGROUND AND OBJECTIVES: Studies in patients with mitral valve prolapse syndrome (MVPS) have shown a variety of forms of autonomic dysfunction, which require further investigation.
SUBJECTS AND METHODS
The study group consisted of 29 male MVP patients, aged 23+/-3 years, and 17 male healthy controls, aged 25+/-2 years. The patients and the control subjects were matched for age and sex. All study subjects underwent a complete echocardiographic examination, and were free of other organic heart diseases and arrhythmia. In a prospective study, the heart rate variability (HRV) indices were calculated from 24-hour Holter recordings, obtained during normal daily activity, and plasma norepinephrine levels measured, and the data between the patients and the controls compared to quantify the autonomic activity.
RESULTS
The HRV indices were significantly greater in the patient than the controls, and revealed hypervagal and mixed type in 55.2 and 20.7% of patients, respectively. There was the greatest parasympathetic activity in the MVPS patients with presyncope or syncope. The MVPS patients with palpitation tended to show hypersympathetic activity, as in the mixed type.
CONCLUSION
Our data suggests that MVPS patients exhibit autonomic dysfunction, mostly resulting from parasympathetic hyperresponsiveness.
