Korean J Gastroenterol.
2000 Jun;35(6):815-819.
A Case of Multiple Myeloma Complicated in Primary Biliary Cirrhosis
Abstract
- Primary biliary cirrhosis with multiple myeloma is very rare, and there have been only 7 case reports in the literature to date. Simultaneous occurrence of primary biliary cirrhosis and multiple myeloma seemed to be related to the hypothesis that chronic antigenemia can result in an expansion of a monoclonal population of B-lymphocytes. The chronic antigenemia is a persistent antigenic stimulation of the reticuloendothelial system, which has been explained through the incapacity of the liver to clear the antigen from the gut. Such clone may be subsequently transformed into a malignant clone by a mutagenic stimulus. We experienced a 52-year-old male patient who had been complaining of generalized pruritus for 9 months. This patient was confirmed to be in early stage of primary biliary cirrhosis complicated by IgG-lamda type multiple myeloma. We compared this case with others reported in literatures.
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