A Clinical Study of Borderline Malignant Tumors of the Ovary

Choi, A N; Kang, J S

Abstract

Borderline tumors which may comprise 10% of ovarian neoplasms, occur predominantly in premenopausal women, and associated with a very good prognosis. This tumor has some but not all of the histologic characteristics of malignancy: stratification of epithelial cells with nuclear atypia and increased mitotic activity but without stromal invasion. The principal treatment of borderline ovarain tumors is surgical resection of the primary tumor. There is no evidence that either subsequent chemotherapy or radiation therapy improves survival. These studies were presented of the forty-three cases of borderline malignant ovarian tumors who had been treated at Korea University Hospital from 1989 to 1995. The follow up period was average 33 months (range, 1 to 77). The incidence of borderline malignant ovarian tumor was 18.9%. The mean age was 38.2 years (range, 18 to 76). The most common chief complaint was palpable mass (37.2%). According to surgical staging (FIGO), stage I and stage III were 40 cases, 3 cases respectively. Histologic subtypes were mucinous in 32 cases (74.4%), serous in 10 cases (23.3%) and mixed epithelial papillary m llerian type in 1 cases (2.3%). All patients underwent primary surgical treatment. Conservative surgery (unilateral oophorectomy or cystectomy) were performed in 25 patients (58.1%) at early stage. Twenty-six cases (60.5%) received adjuvant postoperative chemotherapy. Overall survival rate was 95.3%.