Korean J Helicobacter Up Gastrointest Res.
2012 Jun;12(2):75-81. 10.7704/kjhugr.2012.12.2.75.
Molecular Biology of Upper Gastrointestinal Neoplasms
- Affiliations
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- 1Division of Gastroenterology, Department of Internal Medicine, Incheon St. Mary's Hospital, The Catholic University of Korea, College of Medicine, Incheon, Korea. gastro@catholic.ac.kr
- KMID: 1855192
- DOI: http://doi.org/10.7704/kjhugr.2012.12.2.75
Abstract
- Neoplasms of the upper gastrointestinal tract are related by location and have distinct clinical and molecular characteristics. Malignancies of the upper gastrointestinal tract are often diagnosed at an advanced stage and are generally associated with a poor patient prognosis. Improved understanding of the molecular biology of these tumors should provide new targets for diagnosis, chemoprevention, and therapy. This review focuses on the molecular biology of esophageal adenocarcinoma, esophageal squamous cell carcinoma and gastric adenocarcinoma. Fundamental principles of carcinogenesis are discussed first, followed by the key similarities and differences of each cancer.
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