J Korean Surg Soc.  2011 Jul;81(1):61-65. 10.4174/jkss.2011.81.1.61.

Fibrous hamartoma of infancy: an experience of a single institute

• Kang G
• Suh YL
• Han J
• Kwon GY
• Lee SK
• Seo JM

• KMID: 1853533
• DOI: http://doi.org/10.4174/jkss.2011.81.1.61

Abstract

PURPOSE
Fibrous hamartoma (FH) of infancy is a distinctive fibrous growth that most frequently occurs at birth and during the postnatal period. It is important for clinicians and pathologists to recognize this entity to avoid an aggressive approach.
METHODS
We herein describe the clinicopathologic features of 9 FHs diagnosed at a single institution between 1997 and 2010.
RESULTS
There were 7 boys and 2 girls, and the mean age of presentation was 14.7 months. The common locations were the lower back and gluteal region (n = 3) and scrotum (n = 2). They were solitary lesions, and measured 1.0 to 7.0 cm in maximum diameter (mean, 4.9 cm). The excised masses tended to be poorly circumscribed, and consisted of an intimate mixture of firm, gray-white tissue with fat. Histologically, these lesions were composed of 3 components forming a vague, irregular, organoid pattern: well-defined intersecting trabeculae of fibrocollagenous tissue; loosely textured areas of small, rounded, primitive mesenchymal cells; and mature fat. Over a median follow-up of 72 months, no patient showed recurrence.
CONCLUSION
FH should be distinguished from other forms of fibromatosis and malignant tumors because it is benign and usually cured by local excision.

Keyword

Hamartoma; Infant; Soft tissue neoplasms; Differential diagnosis; Fibromatosis

MeSH Terms

Buttocks
Diagnosis, Differential
Fibroma
Follow-Up Studies
Hamartoma
Humans
Infant
Organoids
Parturition
Scrotum
Soft Tissue Neoplasms

Figure

• 

  Fig. 1 (A) The mass is relatively well-defined, and exhibits rubbery, gray-white fibrous tissue (case no. 5). (B) The lesion is poorly circumscribed, and has a soft, gray-white surface with interposing yellowish fat (case no. 6). (C, D) At scanning power (H&E), there are poorly circumscribed fibrotic (or sclerotic) lesions in the dermis (case no. 3 and 4, respectively). (E, F) The lesions are characterized by an organoid mixture of 3 distinct components: loosely textured area of small, round or spindle, primitive mesenchymal cells, fibrocollagenous tissue and mature fat at ×100 and ×40 magnification (H&E), respectively (case no. 3).

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