Tuberc Respir Dis.  2009 May;66(5):385-389. 10.4046/trd.2009.66.5.385.

A Case of Congenital Cystic Adenomatoid Malformation of the Lng with Atypical Adenomatous Hyperplasia in Adult

• Lee HS
• Choi JS
• Seo KH
• Na JO
• Kim YH
• Oh MH
• Jou SS

• KMID: 1846403
• DOI: http://doi.org/10.4046/trd.2009.66.5.385

Abstract

Congenital cystic adenomatoid malformation (CCAM), which is classified into five types according to size and bronchial invasion, is a rare type of developmental anomaly of the lung. CCAM is occasionally accompanied by malignancy, such as bronchioloalveolar carcinoma (BAC) or rhabdomyosarcoma. As defined by the WHO, atypical adenomatous hyperplasia (AAH) is a non-invasive spread of atypical epithelial cells in single rows along the alveolar wall, within a lesion that is usually less than 5 mm in diameter. AAH was also regarded as a pre-invasive neoplasia, especially associated with BAC and adenocarcinoma. We report a case of type II CCAM with AAH in adults, with a review of the references.

Keyword

Cystic adenomatoid malformation of lung; Congenital

MeSH Terms

Adenocarcinoma
Adenocarcinoma, Bronchiolo-Alveolar
Adult
Cystic Adenomatoid Malformation of Lung, Congenital
Epithelial Cells
Humans
Hyperplasia
Lung
Rhabdomyosarcoma

Figure

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  Figure 1 Chest PA shows cavitary nodule in left hilum.

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  Figure 2 Chest CT shows diffuse ground glass opacity and multiple branching cystic lesion in left lung.

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  Figure 3 The resected lung shows various sized cystic lesion (H&E stain, ×10).

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  Figure 4 The lining cells are pseudostratified ciliated columnar cells to columnar and cuboidal cells like bronchiolar epithelial cells (H&E stain, ×100).

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  Figure 5 Focal mucinous epithelial lesion with mild atypism is revealed in the intervening parenchyma (H&E stain, ×200).

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