Korean J Obstet Gynecol.  2011 Oct;54(10):634-638. 10.5468/KJOG.2011.54.10.634.

A case of squamous cell carcinoma of the uterine cervix with diffuse hematogenous lung metastasis in a 36-year-old virgin

Affiliations
  • 1Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. san1@yuhs.ac
  • 2Department of Obstetrics and Gynecology, The National Health Insurance Corporation Ilsan Hospital, Koyang, Korea.
  • 3Department of Diagnostic Pathology, The National Health Insurance Corporation Ilsan Hospital, Koyang, Korea.

Abstract

The carcinoma of the uterine cervix in virgins is extremely rare. A 36-year-old virgin presented with a 4.8 x 2.2 cm sized endocervical mass with bleeding on sonography. Biopsy revealed a squamous cell carcinoma arising in the uterine cervix without human papilloma virus (HPV) DNA. Positron emission tomography revealed cervical cancer with multiple hematogenous lung metastases. After 3 cycles of preoperative chemotherapy, she underwent modified radical hysterectomy and 6 cycles of postoperative chemotherapy. After the treatment, complete resolution was obtained, and she has been followed without recurrence for 4 years. Although > 90% of cervical cancer is caused by HPV infection, we cannot completely deny the possibility of HPV negative cervical carcinoma.

Keyword

Squamous cell carcinoma; Virgin; Human papilloma virus DNA negative

MeSH Terms

Adult
Biopsy
Carcinoma, Squamous Cell
Cervix Uteri
DNA
Female
Hemorrhage
Humans
Hysterectomy
Lung
Neoplasm Metastasis
Papilloma
Positron-Emission Tomography
Recurrence
Uterine Cervical Neoplasms
Viruses
DNA

Figure

  • Fig. 1 Magnetic resonance imaging demonstrated a 4.8 × 2.2 cm sized mass and it was suspected to be endometrial carcinoma.

  • Fig. 2 Positron emission tomography scan revealed cancer mass confined to the uterine cavity with multiple hematogenous lung metastases.

  • Fig. 3 Gross findings.

  • Fig. 4 (A) Most tumor cells show squamous cell carcinoma, large cell non-keratinizing (H&E, × 200). (B) Positive immunoreactivities for P53 (Immunohistochemistry, × 200).


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