Korean J Obstet Gynecol.  2010 Nov;53(11):1019-1023. 10.5468/kjog.2010.53.11.1019.

Lipoleiomyosarcoma of the uterus: A case report and review

Affiliations
  • 1Center for Uterine Cancer, Research Institute and Hospital, National Cancer Center, Goyang, Korea. sypark.ncc@hotmail.com
  • 2Department of Pathology, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
  • 3Department of Radiology, Research Institute and Hospital, National Cancer Center, Goyang, Korea.
  • 4Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.

Abstract

Heterologous sarcomas of the uterus are rare neoplasms. We report a rare case of heterologous uterine sarcoma composed of leiomyosarcomatous and liposarcomatous components with a brief review of literature. A 53-year-old woman had vaginal spotting. The endometrial biopsy performed at a local clinic revealed a high grade spindle cell sarcoma. Pelvis magnetic resonance imaging showed about 5.4 cm sized multiseptated T1 and T2 high signal mass in a uterine fundus without lymph node metastasis or pelvic wall involvement. Total laparoscopic hysterectomy, bilateral salpingo-oophorectomy, pelvic and para-aortic lymph node dissection, and peritoneal washing cytology were performed. Pathologic diagnosis was made as leiomyosarcoma with liposarcomatous differentiation (lipoleiomyosarcoma). The patient received adjuvant postoperative radiotherapy (5040 cGy). Follow up images showed no evidence of disease 8 months after surgery.

Keyword

Leiomyosarcoma; Liposarcoma; Lipoleiomyosarcoma; Uterus

MeSH Terms

Biopsy
Female
Follow-Up Studies
Humans
Hysterectomy
Leiomyosarcoma
Liposarcoma
Lymph Node Excision
Lymph Nodes
Magnetic Resonance Imaging
Metrorrhagia
Middle Aged
Neoplasm Metastasis
Pelvis
Sarcoma
Uterus

Figure

  • Figure 1 Magnetic resonance image shows multiseptated T1 and T2 high signal mass in a uterine fundus.

  • Figure 2 (A) Gross appearance of the uterine mass: A protruding mass in the endometrial cavity. The tumor is composed of leiomyosarcomatous (B) and liposarcomatous (C) components with abundant myxoid stroma and extensive hemorrhagic necrosis (H&E stain, ×200). The tumor cells are positive for desmin (D), smooth muscle antigen, and CD10 but negative for cytokeratin (E) and epithelial membrane antigen by immunohistochemical staining (×200).


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