J Korean Radiol Soc.  1998 May;38(5):897-902. 10.3348/jkrs.1998.38.5.897.

Renal Damage induced by Doxorubicin-Lipiodol Emulsion infused into Rabbit Renal Artery: Comparison with CT andHistologic Findings

• Kim JG
• Moon TY
• Lee SH
• Kim BS
• Choi SY
• Park CH

• KMID: 1831866
• DOI: http://doi.org/10.3348/jkrs.1998.38.5.897

Abstract

PURPOSE: The purpose of this study was to evaluate the utility of renal CT scanning and to histologicallycorrelate renal damage induced by renal arterial infusion of 0.2 ml/kg of doxorubicin-lipiodol emulsion.
MATERIALS AND METHODS
Renal CT scans of 20 rabbit kidneys were obtained 15 days after transcatheter arterialchemoembolization and were classified into four grades, as follows : Grade 0 - no fleck, Grade 1 - one to threenodular flecks ; Grade 2 - four or more nodular flecks, or one semilunar fleck ; and Grade 3 - two or moresemilunar flecks. The percentage of histological section occupied by lesion was determined using squared paper,and compared with the grades determined on the basis of CT.
RESULTS
The histologic findings were interstitialinflammatory cell infiltration, intratubular lipiodol droplets, dystrophic calcification, and cellular necrosis.The mean sizes of grade 0, 1, 2 and 3 histological lesions were 2.2%(n=5), 4.5%(n=4), 21.9%(n=7), and 24%(n=4),respectively. Grades 0 and 1 accounted for nine cases(3.2%), while grades 2 and 3 accounted for 11(22.6%) ; thisdifference was statistically significant(p<0.01).
CONCLUSION
CT findings showing nodular or semilunar flecks 15days after infusion into the renal artery of doxorubicin-lipiodol emulsion correlate with the size of the damagedkidney, as seen on histological specimens.

Keyword

Kidney, CT; Kidney, interventional procedure

MeSH Terms

Ethiodized Oil
Kidney
Renal Artery*
Tomography, X-Ray Computed
Ethiodized Oil