Infect Chemother.  2010 Oct;42(5):307-310. 10.3947/ic.2010.42.5.307.

A Case of Pneumococcal Endocarditis Accompanied by Arthritis and Meningitis

Affiliations
  • 1Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, Korea. mslee@khmc.or.kr

Abstract

Streptococcus pneumoniae is a common cause of pneumonia. S. pneumoniae also had been a frequent cause of infective endocarditis in the past, but its incidence has markedly decreased after the introduction of effective antibiotics. S. pneumoniae is now a rare cause of this invasive and fatal disease, not to mention S. pneumoniae bacteremia with multiple metastatic infections. We report a 74-year-old woman who presented with arthritis and fever and was diagnosed with infective endocarditis accompanied by meningitis and septic arthritis due to S. pneumoniae without pneumonia. After treatment with antibiotics, the patient recovered without complications. Although S. pneumoniae is a rare cause of infective endocarditis with multiorgan involvement, S. pneumonia should be considered as one of the potential pathogens in such cases.

Keyword

Streptococcus pneumoniae; Infective endocarditis; Meningitis; Septic arthritis

MeSH Terms

Aged
Anti-Bacterial Agents
Arthritis
Arthritis, Infectious
Bacteremia
Endocarditis
Female
Fever
Humans
Incidence
Meningitis
Pneumonia
Streptococcus pneumoniae
Anti-Bacterial Agents

Figure

  • Figure 1 The bone scan of the whole body. Initial bone scan shows increased uptake of the side of the left knee.

  • Figure 2 Changes in transthoracic echocardiographic findings with treatment. Initial transthoracic echocardiogram shows about 14×7 mm sized hypoechoic oscillating mass on the posterior leaflet of the mitral valve (2A, 2B, blue arrow), and mild degree of mitral regurgitation (2C). Follow up echocardiogram shows decreased size of the vegetation to 7.8 mm×6.9 mm (2D, blue arrow).


Reference

1. Thayer WS. Bacterial or infective endocarditis: Gibson lectures for 1930. Edinburgh Med J. 1931. 38:237–265.
2. Aronin SI, Mukherjee SK, West JC, Cooney EL. Review of pneumococcal endocarditis in adults in the penicillin era. Clin Infect Dis. 1998. 26:165–171.
Article
3. Powderly WG, Stanley SL Jr, Medoff G. Pneumococcal endocarditis: report of a series and review of the literature. Rev Infect Dis. 1986. 8:786–791.
Article
4. Bruyn GA, Thompson J, Van der Meer JW. Pneumococcal endocarditis in adult patients. A report of five cases and review of the literature. Q J Med. 1990. 74:33–40.
5. Baik SH, Oh YJ, Choi YH, Shin SS, Park KJ, Hwang SC, Park JH. Infective endocarditis due to Streptococcus pneumoniae. Infect Chemother. 2006. 38:210–213.
6. Kwon JK, Kwon HY, Eun DY, Lee JG, Lee KS, Choi JW, Kwon KT. A case of pneumococcal endocarditis complicated by meningitis. Korean J Med. 2010. 78:138–143.
7. Kim JH, Jo JM, Shin MS, Kim MJ, Chang YJ, Lim H, Choi CM. A case of infective endocarditis with endophthalmitis and septic arthritis caused by pneumococcal bacteremia. Korean J Med. 2010. 78:499–502.
8. Pneumococcal conjugate vaccine for childhood immunization-WHO position paper. Wkly Epidemiol Rec. 2007. 82:93–104.
9. Taylor SN, Sanders CV. Unusual manifestations of invasive pneumococcal infection. Am J Med. 1999. 107:12S–27S.
Article
10. Arai S, Konda T, Wad A, Matsunaga Y, Okabe N, Watanabe H, Inouye S. Use of antiserum-coated latex particles for serotyping Streptococcus pneumoniae. Microbiol Immunol. 2001. 45:159–162.
Article
11. Gentile JH, Sparo MD, Mercapide ME, Luna CM. Adult bacteremic pneumococcal pneumonia acquired in the community. A prospective study on 101 patients. Medicina (B Aires). 2003. 63:9–14.
12. Laupland KB, Gregson DB, Zygun DA, Doig CJ, Mortis G, Church DL. Severe bloodstream infections: a population-based assessment. Crit Care Med. 2004. 32:992–997.
Article
13. Martínez E, Miró JM, Almirante B, Aguado JM, Fernandez-Viladrich P, Fernandez-Guerrero ML, Villanueva JL, Dronda F, Moreno-Torrico A, Montejo M, Llinares P, Gatell JM. Spanish Pneumococcal Endocarditis Study Group. Effect of penicillin resistance of Streptococcus pneumoniae on the presentation, prognosis, and treatment of pneumococcal endocarditis in adults. Clin Infect Dis. 2002. 35:130–139.
Article
14. Dalal A, Ahmad H. Austrian syndrome (pneumococcal pneumonia, meningitis, and endocarditis): a case report. Am J Med Sci. 2008. 336:354–355.
Article
15. Austrian R. Pneumococcal endocarditis, meningitis, and rupture of the aortic valve. AMA Arch Intern Med. 1957. 99:539–544.
Article
16. Lindberg J, Prag J, Schønheyder HC. Pneumococcal endocarditis is not just a disease of the past: an analysis of 16 cases diagnosed in Denmark 1986-1997. Scand J Infect Dis. 1998. 30:469–472.
Article
17. Lefort A, Mainardi JL, Selton-Suty C, Casassus P, Guillevin L, Lortholary O. The Pneumococcal Endocarditis Study Group. Streptococcus pneumoniae endocarditis in adults. A multicenter study in France in the era of penicillin resistance (1991-1998). Medicine (Baltimore). 2000. 79:327–337.
Article
18. Lin SH, Liao WH, Lai CC, Tan CK, Liao CH, Huang YT, Wang CY, Hsueh PR. Comparison of clinical features, antimicrobial susceptibility, serotype distribution and outcomes of patients with hospital- and community-associated invasive pneumococcal disease. Int J Antimicrob Agents. 2010. 36:119–123.
Article
19. Suzuki J, Ando H, Nakajima T, Tamada T, Asada K, Sasaki S. Arthritis and meningitis--the first manifestations of bacterial endocarditis in 2 patients. Jpn Circ J. 1997. 61:450–454.
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