Korean J Hepatobiliary Pancreat Surg.  2014 Nov;18(4):129-137. 10.14701/kjhbps.2014.18.4.129.

Surgical outcome and prognostic factors in patients with gallbladder carcinoma

• Hong EK
• Kim KK
• Lee JN
• Lee WK
• Chung M
• Kim YS
• Park YH

• KMID: 1802228
• DOI: http://doi.org/10.14701/kjhbps.2014.18.4.129

Abstract

BACKGROUNDS/AIMS
Gallbladder carcinoma is usually associated with an unfavorable prognosis, and the clinical outcome has not improved much. This study was conducted to evaluate outcomes with gallbladder carcinoma according to the type of surgery performed, and the prognostic factors for survival.
METHODS
One hundred and six patients with gallbladder carcinoma, who underwent surgery for the purpose of curative resection between January 1999 and June 2012 were reviewed retrospectively.
RESULTS
Out of 106 patients, curative resection was achieved in 75 (70.8%). The cumulative 1-, 2- and 5-year survival rates of the gallbladder carcinoma patients were 93.4%, 80.9% and 63.0%, respectively. Radical resections, including extended cholecystectomy, were more beneficial for long term survival of patients. The 5-year survival rate in patients who underwent curative resection (56.9%) was significantly higher than in those who underwent palliative resection (0%, p=0.000). Multivariate analysis revealed that curative resection, preoperative CA19-9, T-stage, N-stage and differentiation of histology were independently significant prognostic factors.
CONCLUSIONS
Curative resection and early detection of patients with gallbladder carcinoma were the most important factors for long term survival. Radical resection improves survival for patients with localized gallbladder carcinoma and can help to access exact prognosis and treatments.

Keyword

Gallbladder carcinoma; Curative resection; Prognostic factor; Extended cholecystectomy

MeSH Terms

Cholecystectomy
Gallbladder*
Humans
Multivariate Analysis
Prognosis
Retrospective Studies
Survival Rate

Figure

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  Fig. 1 Overall cumulative survival curve of 106 patients with primary gallbladder carcinoma.

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  Fig. 2 Cumulative survival curves according to 7th AJCC staging system.

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  Fig. 3 Cumulative survival curves according to surgical curability (p<0.05).

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  Fig. 4 Cumulative survival curves according to T-stages (p<0.05).

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  Fig. 5 Cumulative survival curves according to N-stages (p<0.05).

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