Korean J Hepatobiliary Pancreat Surg.  2014 Nov;18(4):129-137. 10.14701/kjhbps.2014.18.4.129.

Surgical outcome and prognostic factors in patients with gallbladder carcinoma

Affiliations
  • 1Department of Surgery, Gachon University Gil Medical Center, Incheon, Korea. pyh@gilhospital.com
  • 2Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea.

Abstract

BACKGROUNDS/AIMS
Gallbladder carcinoma is usually associated with an unfavorable prognosis, and the clinical outcome has not improved much. This study was conducted to evaluate outcomes with gallbladder carcinoma according to the type of surgery performed, and the prognostic factors for survival.
METHODS
One hundred and six patients with gallbladder carcinoma, who underwent surgery for the purpose of curative resection between January 1999 and June 2012 were reviewed retrospectively.
RESULTS
Out of 106 patients, curative resection was achieved in 75 (70.8%). The cumulative 1-, 2- and 5-year survival rates of the gallbladder carcinoma patients were 93.4%, 80.9% and 63.0%, respectively. Radical resections, including extended cholecystectomy, were more beneficial for long term survival of patients. The 5-year survival rate in patients who underwent curative resection (56.9%) was significantly higher than in those who underwent palliative resection (0%, p=0.000). Multivariate analysis revealed that curative resection, preoperative CA19-9, T-stage, N-stage and differentiation of histology were independently significant prognostic factors.
CONCLUSIONS
Curative resection and early detection of patients with gallbladder carcinoma were the most important factors for long term survival. Radical resection improves survival for patients with localized gallbladder carcinoma and can help to access exact prognosis and treatments.

Keyword

Gallbladder carcinoma; Curative resection; Prognostic factor; Extended cholecystectomy

MeSH Terms

Cholecystectomy
Gallbladder*
Humans
Multivariate Analysis
Prognosis
Retrospective Studies
Survival Rate

Figure

  • Fig. 1 Overall cumulative survival curve of 106 patients with primary gallbladder carcinoma.

  • Fig. 2 Cumulative survival curves according to 7th AJCC staging system.

  • Fig. 3 Cumulative survival curves according to surgical curability (p<0.05).

  • Fig. 4 Cumulative survival curves according to T-stages (p<0.05).

  • Fig. 5 Cumulative survival curves according to N-stages (p<0.05).


Reference

1. Park JI, Kim JS, Kim KH, Kim KW, Kim KH, Choi CS, et al. Analysis of prognostic factors affecting survival in patients with gallbladder carcinoma. Korean J Hepatobiliary Pancreat Surg. 2010; 14:173–183.
2. Cubertafond P, Gainant A, Cucchiaro G. Surgical treatment of 724 carcinomas of the gallbladder. Results of the French Surgical Association Survey. Ann Surg. 1994; 219:275–280. PMID: 8147608.
Article
3. Foster JM, Hoshi H, Gibbs JF, Iyer R, Javle M, Chu Q, et al. Gallbladder cancer: defining the indications for primary radical resection and radical re-resection. Ann Surg Oncol. 2007; 14:833–840. PMID: 17103074.
Article
4. Shimada H, Endo I, Togo S, Nakano A, Izumi T, Nakagawara G. The role of lymph node dissection in the treatment of gallbladder carcinoma. Cancer. 1997; 79:892–899. PMID: 9041150.
Article
5. Noshiro H, Chijiiwa K, Yamaguchi K, Shimizu S, Sugitani A, Tanaka M. Factors affecting surgical outcome for gallbladder carcinoma. Hepatogastroenterology. 2003; 50:939–944. PMID: 12845954.
6. Choi SB, Han HJ, Kim CY, Kim WB, Song TJ, Suh SO, et al. Fourteen year surgical experience of gallbladder cancer: validity of curative resection affecting survival. Hepatogastroenterology. 2012; 59:36–41. PMID: 22251521.
7. Muratore A, Polastri R, Capussotti L. Radical surgery for gallbladder cancer: current options. Eur J Surg Oncol. 2000; 26:438–443. PMID: 11016462.
Article
8. Shimizu H, Kimura F, Yoshidome H, Ohtsuka M, Kato A, Yoshitomi H, et al. Aggressive surgical approach for stage IV gallbladder carcinoma based on Japanese Society of Biliary Surgery classification. J Hepatobiliary Pancreat Surg. 2007; 14:358–365. PMID: 17653633.
Article
9. Chijiiwa K, Kai M, Nagano M, Hiyoshi M, Ohuchida J, Kondo K. Outcome of radical surgery for stage IV gallbladder carcinoma. J Hepatobiliary Pancreat Surg. 2007; 14:345–350. PMID: 17653631.
Article
10. Benoist S, Panis Y, Fagniez PL. Long-term results after curative resection for carcinoma of the gallbladder. French University Association for Surgical Research. Am J Surg. 1998; 175:118–122. PMID: 9515527.
11. Coburn NG, Cleary SP, Tan JC, Law CH. Surgery for gallbladder cancer: a population-based analysis. J Am Coll Surg. 2008; 207:371–382. PMID: 18722943.
Article
12. Kondo S, Nimura Y, Hayakawa N, Kamiya J, Nagino M, Uesaka K. Extensive surgery for carcinoma of the gallbladder. Br J Surg. 2002; 89:179–184. PMID: 11856130.
Article
13. Donohue JH. Present status of the diagnosis and treatment of gallbladder carcinoma. J Hepatobiliary Pancreat Surg. 2001; 8:530–534. PMID: 11956904.
14. Shirai Y, Wakai T, Hatakeyama K. Radical lymph node dissection for gallbladder cancer: indications and limitations. Surg Oncol Clin N Am. 2007; 16:221–232. PMID: 17336245.
Article
15. Chao TC, Wang CS, Jeng LB, Jan YY, Chen MF. Primary carcinoma of the gallbladder in Taiwan. J Surg Oncol. 1996; 61:49–55. PMID: 8544460.
Article
16. Yamamoto M, Onoyama H, Ajiki T, Yamada I, Fujita T, Saitoh Y. Surgical results of operations for carcinoma of the gallbladder. Hepatogastroenterology. 1999; 46:1552–1556. PMID: 10430293.
17. Kondo S, Nimura Y, Kamiya J, Nagino M, Kanai M, Uesaka K, et al. Factors influencing postoperative hospital mortality and long-term survival after radical resection for stage IV gallbladder carcinoma. World J Surg. 2003; 27:272–277. PMID: 12607050.
Article
18. Lee KY, Ahn SI, Choi YM, Lee KY, Cho YU, Choi SK, et al. Analysis of prognostic factors after surgery for gallbladder cancer. J Korean Surg Soc. 2005; 69:476–481.
19. Park JS, Yoon DS, Kim KS, Choi JS, Lee WJ, Chi HS, et al. Analysis of prognostic factors after curative resection for gallbladder carcinoma. Korean J Gastroenterol. 2006; 48:32–36. PMID: 16861879.
20. Yoo KE, Jo SH, Heo JS, Choi SH, Kim YI, Moon HJ, et al. Surgical outcome and prognostic factors of primary gallbladder carcinoma. J Korean Surg Soc. 2004; 67:384–389.
21. Roa I, Ibacache G, Muñoz S, de Aretxabala X. Gallbladder cancer in Chile: pathologic characteristics of survival and prognostic factors: analysis of 1,366 cases. Am J Clin Pathol. 2014; 141:675–682. PMID: 24713738.
22. You DD, Lee HG, Paik KY, Heo JS, Choi SH, Choi DW. What is an adequate extent of resection for T1 gallbladder cancers? Ann Surg. 2008; 247:835–838. PMID: 18438121.
Article
23. Fetzner UK, Hölscher AH, Stippel DL. Regional lymphadenectomy strongly recommended in T1b gallbladder cancer. World J Gastroenterol. 2011; 17:4347–4348. PMID: 22090793.
Article
24. Lee SE, Jang JY, Kim SW. The surgical strategy for treating T1 gallbladder carcinoma. Korean J Hepatobiliary Pancreat Surg. 2009; 13:69–75.
25. Lee SE, Jang JY, Kim SW, Han HS, Kim HJ, Yun SS, et al. Korean Pancreas Surgery Club. Surgical strategy for T1 gallbladder cancer: a nationwide multicenter survey in South Korea. Ann Surg Oncol. 2014; 21:3654–3660. PMID: 24743905.
Article
26. Box JC, Edge SB. Laparoscopic cholecystectomy and unsuspected gallbladder carcinoma. Semin Surg Oncol. 1999; 16:327–331. PMID: 10332779.
Article
27. Romano F, Franciosi C, Caprotti R, De Fina S, Porta G, Visintini G, et al. Laparoscopic cholecystectomy and unsuspected gallbladder cancer. Eur J Surg Oncol. 2001; 27:225–228. PMID: 11373097.
28. Suzuki K, Kimura T, Ogawa H. Long-term prognosis of gallbladder cancer diagnosed after laparoscopic cholecystectomy. Surg Endosc. 2000; 14:712–716. PMID: 10954815.
Article
29. Wakai T, Shirai Y, Hatakeyama K. Radical second resection provides survival benefit for patients with T2 gallbladder carcinoma first discovered after laparoscopic cholecystectomy. World J Surg. 2002; 26:867–871. PMID: 11960212.
Article
30. Park YJ, Hwang S, Kim KH, Lee YJ, Ahn CS, Moon DB, et al. Prognosis of patients with pT1b/T2 gallbladder carcinoma who have undergone laparoscopic cholecystectomy as an initial operation. Korean J Hepatobiliary Pancreat Surg. 2013; 17:113–117.
Article
31. Chijiiwa K, Nakano K, Ueda J, Noshiro H, Nagai E, Yamaguchi K, et al. Surgical treatment of patients with T2 gallbladder carcinoma invading the subserosal layer. J Am Coll Surg. 2001; 192:600–607. PMID: 11333097.
Article
32. Shirai Y, Ohtani T, Hatakeyama K. Laparoscopic cholecystectomy may disseminate gallbladder carcinoma. Hepatogastroenterology. 1998; 45:81–82. PMID: 9496492.
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