Ann Clin Microbiol.  2015 Mar;18(1):14-19. 10.5145/ACM.2015.18.1.14.

Trends in Bloodstream Infections at a Korean University Hospital between 2008 and 2013

• Oh TS
• Nam YS
• Kim YJ
• Yang HS
• Lee MY
• Gu HJ
• Lee HJ

• KMID: 1800316
• DOI: http://doi.org/10.5145/ACM.2015.18.1.14

Abstract

BACKGROUND
Blood culture remains the definitive method for diagnosing bacteremia and fungemia. In this study, we investigated the incidence of bacterial and fungal infections along with the trends in antimicrobial susceptibility in blood cultures collected from 2008 to 2013.
METHODS
We performed a retrospective analysis of blood cultures performed at Kyung Hee University Hospital, Seoul, South Korea, between 2008 and 2013 to determine the bacterial and fungal species isolated, and their antimicrobial susceptibilities. Additional analyses were performed comparing these results to that of a prior study examining blood cultures collected from 2003-2007.
RESULTS
Of the 102,257 specimens collected, 8,452 (8.3%) were culture positive, with Staphylococcus epidermidis being the most common species isolated (17.3%), followed by Escherichia coli (16.9%), Staphylococcus aureus (8.1%), and Klebsiella pneumoniae (6.5%). Fungal species accounted for 3.7% of all isolates. Methicillin resistance was seen in 54.3% of S. aureus isolates. The frequencies of extended-spectrum beta-lactamase (ESBL)-producing E. coli and K. pneumoniae were 13.1% and 10.3%; imipenem resistance was seen in 19.5% of Pseudomonas aeruginosa isolates.
CONCLUSION
Although the number of blood specimens analyzed increased steadily over the course of this study, the rate of positive blood cultures declined. The most common microorganisms isolated were coagulase-negative staphylococci, E. coli, S. aureus, and K. pneumoniae, consistent with our prior analysis. This analysis of blood culture isolate frequencies and antibiotic susceptibilities can be used to inform antibiotic therapy decisions.

Keyword

Antimicrobial susceptibility; Bacteremia; Bloodstream infections

MeSH Terms

Bacteremia
beta-Lactamases
Escherichia coli
Fungemia
Imipenem
Incidence
Klebsiella pneumoniae
Korea
Methicillin Resistance
Pneumonia
Pseudomonas aeruginosa
Retrospective Studies
Seoul
Staphylococcus aureus
Staphylococcus epidermidis
Imipenem
beta-Lactamases

Figure

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  Fig. 1. Trends in antimicrobial resistance rates in S. aureus, E. coli, K. pneumoniae, E. faecium, P. aeruginosa and A. baumannii. Abbre-viations: MRSA, Methicillin-resistant S. aureus; ESBL ECO, Extended-spectrum β-lactamase-producing E. coli; ESBL KPN, Extended-spec-trum β-lactamase-producing K. pneumoniae; VRE, Vancomycin-re-sistant E. faecium; CRPA, Carbapenem-resistant P. aeruginosa; CRAB, Carbapenem-resistant A. baumannii.

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