J Korean Med Sci.  2014 Jan;29(1):32-37. 10.3346/jkms.2014.29.1.32.

Human Papillomavirus Prevalence and Genotype Distribution among HIV-Infected Women in Korea

Affiliations
  • 1Deparment of Internal Medicine, Pusan National University School of Medicine, Medical Research Institute, Pusan National University Hospital, Busan, Korea. zzanmery@gmail.com
  • 2Deparment of Family Medicine, Yangsan Pusan National University Hospital, Yangsan, Korea.
  • 3Deparment of Obstetrics & Gynecology, Pusan National University Hospital, Busan, Korea.
  • 4Deparment of Pathology, Pusan National University Hospital, Busan, Korea.

Abstract

The epidemiology on human papillomavirus (HPV) among human immunodeficiency virus (HIV)-infected women in Korea is not well established. A retrospective study was conducted to determine the prevalence and genotype distribution of HPV infection among HIV-infected women in Korea. HPV DNA genotype and cervical cytology were examined in 60 HIV-positive women and 1,938 HIV-negative women. HPV genotypes were analyzed by using a HPV DNA chip. HIV-infected women had higher prevalence of high-risk HPV (hr-HPV) infection (30% vs 4.9%, adjusted odds ratio [AOR], 6.96; 95% confidence interval [CI], 3.63-13.34, P<0.001) and abnormal cervical cytology (18.3% vs 1.8%, AOR, 10.94; 95% CI, 5.18-23.1, P<0.001) compared with controls. The most common hr-HPV genotype detected in HIV-infected women was HPV 16 (10%), followed by 18 (6.7%) and 52 (5%). Prevalence of quadrivalent vaccine-preventable types (HPV 6, 11, 16, and 18) was 21.7% and 2.3% in HIV-positive women and HIV-negative women, respectively. Age was a significant risk factor for hr-HPV infection in HIV-infected women (P=0.039). The presence of hr-HPV was significantly associated with abnormal cervical cytology (P<0.001). These findings suggest that HPV testing for cervical cancer screening in HIV-infected women would be necessary, particularly among young age group.

Keyword

HIV; Women; Human Papillomavirus; Prevalence; Genotype

MeSH Terms

Adult
Age Factors
Cervix Uteri/virology
DNA Probes, HPV/diagnostic use
DNA, Viral/genetics
Female
Genotype
HIV Infections/complications/*epidemiology/genetics
HIV-1/genetics
Human papillomavirus 11/genetics/isolation & purification
Human papillomavirus 16/genetics/isolation & purification
Human papillomavirus 18/genetics/isolation & purification
Human papillomavirus 6/genetics/isolation & purification
Humans
Middle Aged
Papillomavirus Infections/complications/*epidemiology/*genetics
Prevalence
Republic of Korea/epidemiology
Retrospective Studies
Risk Factors
Uterine Cervical Neoplasms/epidemiology/genetics/virology
DNA Probes, HPV
DNA, Viral
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