J Korean Med Sci.  2009 Feb;24(1):114-119. 10.3346/jkms.2009.24.1.114.

Clinical Characteristics of Metastatic Tumors to the Ovaries

• Lee SJ
• Bae JH
• Lee AW
• Tong SY
• Park YG
• Park JS

• KMID: 1794416
• DOI: http://doi.org/10.3346/jkms.2009.24.1.114

Abstract

Approximately 5-30% of the ovarian cancers are metastatic malignancies. The prevalence of metastatic ovarian tumors varies with the incidence rates and spread patterns of primary malignancies. We evaluated the prevalence, pre- and postoperative characteristics of metastatic ovarian cancer in Korean women. We reviewed the records for 821 ovarian malignancies with pathological consultation from 1996- 2006 and recorded patient demographical, radiological, histopathological, and survival data. The study included 112 cases of histologically confirmed metastatic ovarian cancer. Metastatic ovarian cancer accounted for 13.6% of all ovarian malignancy, primarily arising from the gastrointestinal tract. The preoperative detection rate with imaging was 75%, and none of the radiological or serological features were useful for differential diagnosis. In multivariate analysis for prognostic variables, the only significant factor was the primary tumor site (p=0.004). Furthermore, extensive resection increased survival for some patients. The differential diagnosis of metastatic ovarian cancer can be problematic, so multiple diagnostic approaches are necessary. The extent of cytoreductive surgery for this type of tumor must be decided on a case-by-case basis.

Keyword

Metastasis; Ovary; Prevalence; Diagnostic Imaging; Surgical Procedures

MeSH Terms

Adenocarcinoma/*diagnosis/*secondary/surgery
Adult
CA-125 Antigen/blood
Data Interpretation, Statistical
Diagnosis, Differential
Female
Gastrointestinal Neoplasms/diagnosis/pathology
Humans
Medical Records
Middle Aged
Ovarian Neoplasms/*diagnosis/*secondary/surgery
Ovariectomy
Prognosis
Retrospective Studies
Risk Factors
Survival Analysis

Figure

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  Fig. 1 Survival rates of patients with metastatic ovarian cancer according to primary tumor origin.

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  Fig. 2 Survival rates for patients according to extent of cytoreductive surgery.

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