J Korean Med Sci.  2009 Feb;24(1):92-96. 10.3346/jkms.2009.24.1.92.

Fibrin Glue Reduces the Duration of Lymphatic Drainage after Lumpectomy and Level II or III Axillary Lymph Node Dissection for Breast Cancer: A Prospective Randomized Trial

• Ko E
• Han W
• Cho J
• Lee JW
• Kang SY
• Jung SY
• Kim EK
• Hwang KT
• Noh DY

• KMID: 1794412
• DOI: http://doi.org/10.3346/jkms.2009.24.1.92

Abstract

This randomized prospective study investigated the effect of fibrin glue use on drainage duration and overall drain output after lumpectomy and axillary dissection in breast cancer patients. A total of 100 patients undergoing breast lumpectomy and axillary dissection were randomized to a fibrin glue group (N=50; glue sprayed onto the axillary dissection site) or a control group (N=50). Outcome measures were drainage duration, overall drain output, and incidence of seroma. Overall, the fibrin glue and control groups were similar in terms of drainage duration, overall drain output, and incidence of seroma. However, subgroup analysis showed that fibrin glue use resulted in a shorter drainage duration (3.5 vs. 4.7 days; p=0.0006) and overall drain output (196 vs. 278 mL; p=0.0255) in patients undergoing level II or III axillary dissection. Fibrin glue use reduced drainage duration and overall drain output in breast cancer patients undergoing a lumpectomy and level II or III axillary dissection.

Keyword

Fibrin Tissue Adhesive; Axillary Lymph Node Excision; Lymphatic Drainage; Breast Neoplasms

MeSH Terms

Adult
Axilla
Breast Neoplasms/pathology/*surgery
Drainage
Female
Fibrin Tissue Adhesive/*therapeutic use
Humans
*Lymph Node Excision
*Mastectomy, Segmental
Middle Aged
Prospective Studies
Seroma/epidemiology/etiology
Severity of Illness Index
Time Factors
Tissue Adhesives/*therapeutic use

Figure

• 

  Fig. 1 Study flow chart. BMI, body mass index; body weight (kg)/height2 (m2). *Five patients with postoperative bleeding were excluded.

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