J Korean Med Sci.  2010 Jul;25(7):1045-1052. 10.3346/jkms.2010.25.7.1045.

Cardiovascular Parameters Correlated with Metabolic Syndrome in a Rural Community Cohort of Korea: The ARIRANG Study

• Ahn MS
• Kim JY
• Youn YJ
• Kim SY
• Koh SB
• Lee K
• Yoo BS
• Lee SH
• Yoon J
• Park JK
• Choe KH

• KMID: 1792955
• DOI: http://doi.org/10.3346/jkms.2010.25.7.1045

Abstract

Although metabolic syndrome (MetS) is associated with increased cardiovascular mortality and the development of atherosclerosis, consensus is still lacking on the status of cardiovascular function and geometry in MetS patients. We investigated the relation between MetS and left ventricle (LV) geometry and function, carotid intima-media thickness (IMT) and arterial stiffness in a community-based cohort of 702 adult subjects. Subjects were categorized into three groups according to the number of MetS components present, as defined by the Adult Treatment Panel III guidelines: 1) Absent (0 criteria), 2) Pre-MetS (1-2 criteria) or 3) MetS (> or =3 criteria). In female subjects, LV mass, LV mass/height(2.7), deceleration time, and aortic pulse wave velocity increased, and E/A ration decreased in a stepwise manner across the three groups. These changes were not observed in male subjects. The mean carotid IMT was higher in the MetS group than in the other two groups. The degree of MetS clustering is found to be strongly correlated with geometric eccentricity of LV hypertrophy, diastolic dysfunction and arterial changes irrespective of age and blood pressure status, particularly in females. Waist circumference is found to have the most powerful effect on cardiovascular parameters.

Keyword

Metabolic Syndrome; Heart Ventricles; Geometry; Intima-media Thickness; Pulse Wave Velocity

MeSH Terms

Adult
Aged
Cardiovascular Diseases/etiology/*physiopathology
Cardiovascular System/pathology/*physiopathology
Carotid Arteries/anatomy & histology/physiology
*Cohort Studies
Female
Heart Ventricles/anatomy & histology
Humans
Korea
Male
Metabolic Syndrome X/complications/*physiopathology
Middle Aged
*Rural Population
Ventricular Function, Left/physiology

Figure

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  Fig. 1 Carotid intima-media thickness analyzed using ANCOVA, adjusted for age, blood pressure, and smoking status, according to the number of metabolic syndrome criteria present.

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  Fig. 2 Regional pulse wave velocity in males analyzed by ANCOVA adjusted for age, blood pressure, and smoking status, according to the number of metabolic syndrome criteria present. hrPWV, heart-to-radial pulse wave velocity; faPWV, femoral-to-ankle pulse wave velocity.

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  Fig. 3 Regional pulse wave velocity in females analyzed by ANCOVA adjusted for age, blood pressure, and smoking status, according to the number of metabolic syndrome criteria present. hrPWV, heart-to-radial pulse wave velocity; faPWV, femoral-to-ankle pulse wave velocity.

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