J Korean Med Sci.  2010 Apr;25(4):634-637. 10.3346/jkms.2010.25.4.634.

Primary Squamous Cell Carcinoma in the Testis: A Case Report

• Kim NR
• Cho HY
• Yoon SJ
• Park JH
• Ha SY

• KMID: 1792938
• DOI: http://doi.org/10.3346/jkms.2010.25.4.634

Abstract

A 51-yr-old man presented with an enlarged right testis for two months. The radically resected testis showed a relatively well-circumscribed ovoid mass, nearly replacing the normal architecture with central cystic changes. Microscopically, the mass was composed of ovoid shaped tumor cells of a moderately differentiated squamous cell carcinoma (SCC). The central portion of the mass was filled with well-formed laminated keratinous materials and the remnant cavity lined by dysplastic squamous epithelium, indicated SCC may be derived from an epidermal cyst. SCC is among the most common types of neoplasm afflicting human beings, but it is rare in the testis. To our knowledge, this is the second report of the testicular squamous cell carcinoma occurring in a patient without other primary tumors, and the firstly reported case in Korea.

Keyword

Carcinoma, Squamous Cell; Testis

MeSH Terms

Carcinoma, Squamous Cell/diagnosis/*pathology
Humans
Korea
Male
Middle Aged
Testicular Neoplasms/diagnosis/*pathology

Figure

• 

  Fig. 1 Abdominal computed tomography shows a well-circumscribed oval shaped mass with heterogeneous internal density (arrow).

• 

  Fig. 2 Photograph of the resected specimen shows that an oval shaped mass nearly replaces the testis. Arrow indicates a hydrocele.

• 

  Fig. 3 Histopathological findings of the testis. (A) Nests of squamous cell carcinoma show wall infiltration (H&E stain, ×200). (B) High magnification of neoplastic squamous cells shows orangeophilic cytoplasm and intercellular bridges (H&E stain, ×400). (C) Central cyst, probably epidermal cyst, is filled with laminated linear keratinous materials (×40). Inset indicates foreign body reaction (H&E stain, ×400). (D) The cyst wall is focally lined by mature squamous epithelium (×100). Inset indicates transformation into dysplastic squamous cells (H&E stain, ×1,000).

Reference

1. Nistal M, Gonzalez-Peramato P, Paniagua R. Secondary testicular tumors. Eur Urol. 1989. 16:185–188.

2. Bryan RL, Liu S, Newman J, O'Brien JM, Considine J. Squamous cell carcinoma arising in a chronic hydrocoele. Histopathology. 1990. 17:178–180.

3. Shih DF, Wang JS, Tseng HH. Primary squamous cell carcinoma of the testis. J Urol. 1996. 156:1772.

4. Pienkos EJ, Jablokow VR. Secondary testicular tumors. Cancer. 1972. 30:481–485.

5. Smallman LA, Odedra JK. Primary carcinoma of sigmoid colon metastasizing to epididymis. Urology. 1984. 23:598–599.

6. Shah KH, Maxted WC, Chun B. Epidermoid cysts of the testis. A report of three cases and an analysis of four cases from the world literature. Cancer. 1981. 47:577–582.