Korean J Gastroenterol.  2012 May;59(5):338-346. 10.4166/kjg.2012.59.5.338.

Clinical Characteristics of Patients Diagnosed as Peptic Ulcer Disease in the Third Referral Center in 2007

• Kim JJ
• Kim N
• Park HK
• Jo HJ
• Shin CM
• Lee SH
• Park YS
• Hwang JH
• Kim JW
• Jeong SH
• Lee DH
• Kim JM
• Lee JH
• Jung HC
• Song IS

• KMID: 1792832
• DOI: http://doi.org/10.4166/kjg.2012.59.5.338

Abstract

BACKGROUND/AIMS
In spite of the improvement of medical treatment for the peptic ulcer disease (PUD), PUD is still one of the common upper gastrointestinal diseases. The purpose of this study was to evaluate the risk factors and general characteristics of Korean patients diagnosed as PUD at a single third referral center.
METHODS
A total of 310 patients, diagnosed as PUD through endoscopy during one year of 2007 at Seoul National University Bundang Hospital were, retrospectively, evaluated regarding age, gender, Helicobacter pylori (H. pylori) positivity, clinical manifestations, comorbidities and medications. In addition, PUD was analyzed in the aspect of ulcer location, type of visit, gastrointestinal bleeding, and age.
RESULTS
The mean age was 61.5 years old (48.1% over 65) and 208 (66.7%) patients were men. The rate of H. pylori infection was 47.8%, and any ulcerogenic medication history such as antiplatelet agents and NSAIDs was found to be 21.0% (65 patients). The rate of idiopathic peptic ulcer without evidence of H. pylori and NSAIDs was found to be 40.6% (126 patients). Among 310 PUD patients, bleeding symptoms such as melena, hematemesis and hematochezia occurred in 110 patients (35.5%).
CONCLUSIONS
PUD was more prevalent in the elderly patients and frequently associated with bleeding. Substantial proportion of PUD patients had neither H. pylori infection nor history of ulcerogenic medications, suggesting of increasing prevalence of idiopathic PUD.

Keyword

Peptic ulcer; Risk factors; Helicobacter pylori; Nonsteroidal anti-inflammatory drugs; Bleeding

MeSH Terms

Adult
Age Factors
Aged
Aged, 80 and over
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
Female
Gastrointestinal Hemorrhage
Gastroscopy
Helicobacter Infections/complications/diagnosis
Helicobacter pylori
Hematemesis
Humans
Male
Melena
Middle Aged
Peptic Ulcer/*diagnosis/drug therapy/epidemiology
Platelet Aggregation Inhibitors/therapeutic use
Prevalence
Referral and Consultation
Retrospective Studies
Risk Factors
Sex Factors

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