Korean J Gastroenterol.  2009 Jul;54(1):5-12. 10.4166/kjg.2009.54.1.5.

Management of Antibiotics-Associated Diarrhea

• Park HS
• Han DS

• KMID: 1792760
• DOI: http://doi.org/10.4166/kjg.2009.54.1.5

Abstract

Antibiotics-associated diarrhea (AAD) is defined as unexplained diarrhea that occurs with the administration of antibiotics. Approximately 20% AAD cases are due to Clostridium difficile. Over the last decade, the incidence of Clostridium difficile-associated disease (CDAD) has progressively increased, and now a significant clinical problem. Recent change in the epidemiology of CDAD and the emergence of an epidemic hypervilruent strain suggest the need for greater attention for infection control, early diagnosis, and more effective treatment modality. However, since most cases of CDAD are both iatrogenic and nosocomial, careful selection of antibiotics, combined with proper hand hygiene and precaution by medical staffs are required.

Keyword

Antibiotics-associated diarrhea (AAD); C. difficile; Clostridium difficile-associated disease (CDAD)

MeSH Terms

Anti-Bacterial Agents/*adverse effects/therapeutic use
*Clostridium difficile
Diarrhea/*etiology
Enterocolitis, Pseudomembranous/diagnosis/*etiology/therapy
Humans
Immunotherapy
Recurrence