Gut Liver.  2014 Jul;8(4):408-414.

Treatment Outcome for Gastric Mucosa-Associated Lymphoid Tissue Lymphoma according to Helicobacter pylori Infection Status: A Single-Center Experience

Affiliations
  • 1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. doc0224@pusan.ac.kr

Abstract

BACKGROUND/AIMS
Helicobacter pylori eradication therapy has been used as a first-line treatment for H. pylori-positive gastric mucosa-associated lymphoid tissue (MALT) lymphoma. However, the management strategy for H. pylori-negative MALT lymphoma remains controversial. Therefore, the aim of this study was to examine the success rate of each treatment option for H. pylori-positive and H. pylori-negative gastric MALT lymphomas.
METHODS
In total, 57 patients with gastric MALT lymphoma diagnosed between December 2000 and June 2012 were enrolled in the study. The treatment responses were compared between H. pylori-positive and H. pylori-negative gastric MALT lymphomas.
RESULTS
Of the 57 patients, 43 (75%) had H. pylori infection. Forty-eight patients received H. pylori eradication as a first-line treatment, and complete remission was achieved in 31 of the 39 patients (80%) with H. pylori-positive MALT lymphoma and in five (56%) of the nine patients with H. pylori-negative MALT lymphoma; no significant difference was observed between the groups (p=0.135). The other treatment modalities, including radiation therapy, chemotherapy, and surgery, were effective irrespective of H. pylori infection status, with no significant difference in the treatment response between H. pylori-positive and H. pylori-negative MALT lymphomas.
CONCLUSIONS
H. pylori eradication therapy may be considered as a first-line treatment regardless of H. pylori infection status.

Keyword

Lymphoma, B-cell, marginal zone; Stomach; Helicobacter pylori; Eradication; Radiotherapy

MeSH Terms

Adult
Aged
Antineoplastic Agents/therapeutic use
Female
Gastric Mucosa
Gastroscopy/*methods
Helicobacter Infections/complications/*therapy
*Helicobacter pylori
Humans
Lymphoma, B-Cell, Marginal Zone/complications/*therapy
Male
Middle Aged
Retrospective Studies
Stomach Neoplasms/complications/*therapy
Treatment Outcome
Antineoplastic Agents
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