Korean J Parasitol.  2014 Apr;52(2):197-199.

Two Human Cases of Diphyllobothrium nihonkaiense Infection in Korea

Affiliations
  • 1Department of Parasitology and Tropical Medicine, Kyungpook National University School of Medicine, Daegu 700-422, Korea. kuku1819@knu.ac.kr
  • 2Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 700-422, Korea.

Abstract

Diphyllobothrium latum and Diphyllobothrium nihonkaiense are the 2 reported main causes of human diphyllobothriasis in the Republic of Korea. However, the differentiation of these 2 species based on morphologic features alone is difficult. The authors used nucleotide sequencing of the mitochondrial cytochrome c oxidase subunit 1 (cox1) gene to diagnose Diphyllobothrium spp. Two patients visited the emergency room at Kyungpook National University Hospital on 3 April and 12 April 2013, respectively, with fragments of parasites found while defecating. The parasites were identified as Diphyllobothrium spp. based on morphologic characteristics, and subsequent cox1 gene sequencing showed 99.9% similarity (1,478/1,480 bp) with D. nihonkaiense. Our findings support the hypothesis that D. nihonkaiense is a dominant species in Korea.

Keyword

Diphyllobothrium nihonkaiense; human case; praziquantel; cox1 gene

MeSH Terms

Adult
Animals
Anthelmintics/therapeutic use
Base Sequence
DNA, Helminth/*genetics
Diphyllobothriasis/*diagnosis/drug therapy
Diphyllobothrium/*genetics
Electron Transport Complex IV/*genetics
Humans
Male
Middle Aged
Mitochondria/enzymology
Phylogeny
Praziquantel/therapeutic use
Republic of Korea
Sequence Analysis, DNA
Young Adult
Anthelmintics
DNA, Helminth
Electron Transport Complex IV
Praziquantel
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