Ann Lab Med.  2014 Sep;34(5):405-407. 10.3343/alm.2014.34.5.405.

False-Positive Elevation of Creatine Kinase MB Mass Concentrations Caused by Macromolecules in a Patient who Underwent Nephrectomy for Renal Cell Carcinoma

Affiliations
  • 1Department of Laboratory Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. uthmd@hanmail.net
  • 2Department of Urology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea.

Abstract

No abstract available.


MeSH Terms

Aged
Carcinoma, Renal Cell/*diagnosis/surgery
Coronary Angiography
Creatine Kinase, MB Form/analysis/*metabolism
Echocardiography
Electrophoresis
Enzyme-Linked Immunosorbent Assay
False Positive Reactions
Humans
Kidney Neoplasms/*diagnosis/surgery
Male
Nephrectomy
Creatine Kinase, MB Form

Figure

  • Fig. 1 Biochemical results of the patient. CK-MB mass concentrations and CK activity increased at three days after the surgery. However, troponin I level were normal, and the results of the transthoracic echocardiogram and cardiac angiography were unremarkable. During the week following admission, the patient's CK-MB mass concentration using CK-MB VIDAS test (Vidas-Biomerieux, Marcy-I'Etoile, France) increased to more than 300 µg/L, but the CK-MB mass concentrations with sample dilutions were not linear. 98.3% of the CK-MB mass concentration decreased by PEG precipitation. CK-MB mass concentrations using another immunoenzymatic reagent (Elecsys Creatine Kinase MB, Roche Diagnostics, GmbH, Mannheim, Germany) was within reference range.Abbreviations: CK, creatine kinase; CK-MB, creatine kinase MB isoenzyme; HBT, heterophilic blocking tube; PEG, polyethylene glycol.


Reference

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