Korean J Dermatol.  1999 Jul;37(7):944-947.

Subepidermal Blistering Diseases with Coexistent IgG and IgA Anti-BMZ Antibodies: Epidermolysis and Cicatricial Pemphigoid

• Lee CW
• Kim JS

Abstract

A 21 year-old lady had erythemas and bullae on the trunk for 20 days. Biopsy specimens showed subepidermal blister and deposits of IgG and IgA along the basement membrane zone (BMZ). Her serum antibodies of IgG and IgA were observed to recognize 290/145 kD antigens derived from A431-cell line. The other patient of 62 year-old woman had recurrent oral erosions and erosio-ulcerative plaques on her anterior chest for the past 2 years. Tissue specimens showed subepidermal blister and deposits of IgG and IgA at the BMZ. The patients serum had IgG and IgA antibodies which had binding specificities to the 230 kD pemphigoid antigen. The above two cases of epidermolysis billosa acquisita and cicatricial pemphigoid with IgG and IgA antibodies of comparable titers in each may be rarely encountered ones.

Keyword

Epidermolysis bullosa acquisita; Cicatricial pemphigoid

MeSH Terms

Antibodies*
Basement Membrane
Biopsy
Blister*
Epidermolysis Bullosa Acquisita
Erythema
Female
Humans
Immunoglobulin A*
Immunoglobulin G*
Middle Aged
Pemphigoid, Benign Mucous Membrane*
Pemphigoid, Bullous
Thorax
Young Adult
Antibodies
Immunoglobulin A
Immunoglobulin G