Korean J Intern Med.  2010 Jun;25(2):213-216. 10.3904/kjim.2010.25.2.213.

Two Lung Masses with Different Responses to Pemetrexed

• Park KY
• Jung JW
• Nam SB
• Lee HJ
• Kim HS
• Choi YH
• Lee JC

• KMID: 1785681
• DOI: http://doi.org/10.3904/kjim.2010.25.2.213

Abstract

We described here a patient who had two lung masses. Although the two masses had the same histology and a similar good response to initial chemotherapy with gemcitabine and carboplatin, the response to pemetrexed as a second-line treatment was different after re-growth of the tumors. These two lung masses could have originated from different clones or they could have progressed through different paths of molecular pathogenesis after metastasis, which would lead to different tumor characteristics, including their chemosensitivity. Regardless of their pathogenetic mechanisms, it seems important to recognize that tumors with the same histology that develop in one patient can have different responses to drugs.

Keyword

Lung neoplasms; Pemetrexed; Neoplasms, multiple primary; Drug resistance

MeSH Terms

Aged
Antimetabolites, Antineoplastic/*therapeutic use
Antineoplastic Agents/therapeutic use
Carboplatin/therapeutic use
Carcinoma, Squamous Cell/*drug therapy/pathology
Deoxycytidine/analogs & derivatives/therapeutic use
Drug Resistance, Neoplasm
Female
Glutamates/*therapeutic use
Guanine/*analogs & derivatives/therapeutic use
Humans
Lung Neoplasms/*drug therapy/pathology
Neoplasms, Second Primary/*drug therapy/pathology