Korean J Intern Med.  2007 Sep;22(3):192-196. 10.3904/kjim.2007.22.3.192.

Pulmonary Nodular Lymphoid Hyperplasia Associated with Sj?gren's Syndrome

• Song MK
• Seol YM
• Park YE
• Kim YS
• Lee MK
• Lee CH
• Jeong YJ

• KMID: 1785626
• DOI: http://doi.org/10.3904/kjim.2007.22.3.192

Abstract

Pulmonary nodular lymphoid hyperplasia (NLH) is a term first suggested by Kradin and Mark to describe one or more pulmonary nodules or localized lung infiltrates consisting of reactive lymphoid proliferation. To date, there have been only a few cases of pulmonary NLH reported associated with autoimmune disorders. There is no case of NLH associated with Sj?gren's syndrome from Korea in the medical literature. A 56-year-old woman was referred to our hospital with cough productive of sputum and chest tightness. The Computed tomography scans of the chest revealed multiple and well-defined peribronchiolar nodular opacities. A video assisted thoracoscopic surgery (VATS) biopsy was performed and the nodular opacity in the lung parenchyma was pathologically confirmed as NLH. Through meticulous review of patient's record, we found that she had been suffering from dry eye and dry mouth. The symptoms suggested Sj?gren's syndrome, which was confirmed by specific laboratory tests including the Schirmer test, anti-nuclear antibody and anti-Ro/La antibody. The patient is followed regularly and has no further progression of symptoms.

Keyword

Pseudolymphoma; Pulmonary nodular hyperplasia; Sj?gren's syndrome

MeSH Terms

Biopsy
Female
Humans
Immunohistochemistry
Middle Aged
Pseudolymphoma/complications/*pathology/*radiography
Sjogren's Syndrome/*complications
Thoracic Surgery, Video-Assisted
Tomography, X-Ray Computed