J Korean Acad Periodontol.  2009 Mar;39(1):87-94. 10.5051/jkape.2009.39.1.87.

The clinical effects of a hydroxyapatite containing toothpaste for dentine hypersensitivity

• Kim SH
• Park JB
• Lee CW
• Koo KT
• Kim TI
• Seol YJ
• Lee YM
• Ku Y
• Chung CP
• Rhyu IC

• KMID: 1783520
• DOI: http://doi.org/10.5051/jkape.2009.39.1.87

Abstract

PURPOSE: The aim of this study was to compare the effectiveness of hydroxyapatite containing toothpaste with positive control toothpastes in reducing dentine hypersensitivity.
MATERIALS AND METHODS
This clinical trial was a double-blind, randomized, parallel group comparison of two, namely hydroxyapatite containing toothpaste and strontium chloride containing toothpaste. A total of 55 subjects were included in this study. The subjects were given randomly assigned one of the two toothpastes after received tooth brushing instruction at baseline. Some clinical indices(PI, GI, PD), verbal rating score(VRS) for sensitivity to stimulus, the effect in relieving sensitivity and visual analogue scale(VAS) for sensitivity at baseline, week 2, week 4 and week 8 were assessed. All data were evaluated by intention-to-treat analysis.
RESULTS
Overall, PI and GI scores were significantly reduced compare baseline in all groups(p<0.05). In addition, there was significant difference in PI at 4 weeks and in GI at 4, 8 weeks between groups. The proportions of subjects relieved sensitivity were 70.4% in experimental group and 57.1% in control group at 8 weeks respectively. The VRS for sensitivity to three kinds of stimuli and VAS for sensitivity decreased according to time, there was no overall difference between two groups(p>0.05).
CONCLUSION
This study demonstrated that the new hydroxyapatite containing toothpaste was similarly effective in reducing dentine hypersensitivity with pre-existing benchmark toothpaste.

Keyword

clinical trial; dentine hypersensitivity; hydroxyapatite; toothpaste

MeSH Terms

Dentin
Dentin Sensitivity
Durapatite
Strontium
Tooth
Toothpastes
Durapatite
Strontium
Toothpastes

Figure

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  Figure 1 Distribution of examined teeth.

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  Figure 2 The verbal rating score(VRS) for sensitivity to cold stimulus at baseline, week 2, week 4 and week 8 between experimental and control groups.

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  Figure 3 The verbal rating score(VRS) for sensitivity to air stimulus at baseline, week 2, week 4 and week 8 between experimental and control groups.

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  Figure 4 The verbal rating score(VRS) for sensitivity to tactile stimulus at baseline, week 2, week 4 and week 8 between experimental and control groups.

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  Figure 5 The effect in relieving sensitivity at baseline, week 2, week 4 and week 8 on each group.

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  Figure 6 Change of visual analogue scale(VAS) for sensitivity at baseline, week 2, week 4 and week 8 between experimental and control groups.

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