Yonsei Med J.  2008 Dec;49(6):1052-1054. 10.3349/ymj.2008.49.6.1052.

Gastric Schwannoma

• Yoon HY
• Kim CB
• Lee YH
• Kim HG

• KMID: 1782958
• DOI: http://doi.org/10.3349/ymj.2008.49.6.1052

Abstract

Schwannomas, also known as neurinomas or neurilemmomas, are generally benign, slow-growing neoplasms originating in any nerve that has a Schwann cell sheath. These neoplasms are rare among the spindle cell mesenchymal tumors of the gastrointestinal tract, but develop most commonly in the stomach representing 0.2% of all gastric tumors. We present the case of a 57-year-old female patient with a large schwannoma in the stomach that was palpable in the abdomen. She underwent subtotal gastrectomy under suspicion of gastrointestinal stromal tumor (GIST), but post-operative histopathological and immunohistochemical findings showed a fascicular arrangement of spindle cell with pallisading nuclei, and positive for S-100 protein with negative smooth muscle actin (SMA). These results confirmed schwannoma as the diagnosis.

Keyword

Schwannoma; stomach; submucosal tumor; S-100 protein

MeSH Terms

Diagnosis, Differential
Female
Gastrointestinal Stromal Tumors/diagnosis
Humans
Immunohistochemistry
Middle Aged
Neurilemmoma/*diagnosis/metabolism
S100 Proteins/metabolism
Stomach Neoplasms/*diagnosis/metabolism

Figure

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  Fig. 1 Barium upper gastrointestinal study shows a large submucosal tumor noted in gastric angle without mucosal ulceration (black arrows).

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  Fig. 2 Abdomen computed tomography reveals a large soft tissue mass lesion along lesser curvature side of stomach (black arrow).

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  Fig. 3 Abdomen sonography reveals a homogeneous, hypoechoic and kidney bean shaped mass.

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  Fig. 4 Surgical specimen is seen a intramural fungating nodular solid mass.

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  Fig. 5 Immunochemistry stain shows the bundles of spindle cell with brown color, positive to S-100 protein (S-100 stain, × 200).

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